Muscle Flashcards
Where is CK-MB found?
Heart
Where is CK-MM found?
Muscle
Where is CK-BB found?
Brain
Why should you wait 30 min after a meal before swimming?
All blood in gut and skeletal muscle have ran out of ATP
How does a neurogenic muscle disease present?
Distal weakness + fasciculations
How does a myopathic muscle disease present?
Proximal weakness + pain
What is a light chain composed of?
Actin
What is a heavy chain composed of?
Myosin
What band of the sarcomere does not change length?
A band
Where are the T tubules located?
Cardiac muscle: Z line
Skeletal muscle: A-I junction
Duchenne’s Muscular Dystrophy
Dystrophin frameshift, Gower sign, Cale pseudohypertrophy
Becker’s Muscular Dystrophy
Dystrophin missense, symptoms > 5yo
Myotonic Dystrophy
Birds beak face, can’t let go when shaking hands
Myasthenic Syndrome = Lambert-Eaton
Gets stronger as day goes by, stronger with EMG, not small cell CA associated
Myasthenia Gravis
Gets weaker as day goes by, stronger with Edrophonium, weaker with EMG, rule out thymoma
Multiple Sclerosis
Anti-myelin antibody, young woman with vision problems, symptoms come and go
Metachromatic Leukodystrophy
Arylsulfatase deficiency, kid with MS presentation
Ataxia Telangectasia
Spider veins, IgA deficiency
Freidrich’s Ataxia
Retinitis pigmentosa, scoliosis
Adrenal Leukodystrophy
Carnitine shuttle problem, adrenal failure
Guillane-Barre
Ascending paralysis, 2 weeks after URI
ALS - Amyotrophic Lateral Sclerosis aka Lou Gehrig’s Disease
Middle age male with fasciculations, descending paralysis, no sensory problems
Werdnig-Hoffman
Fasciculations in a newborn, no anterior horns
Polio
Asymmetric fasciculations in child, 2 weeks after gastroenteritis
Choreoathetosis
Dance-like movements, wringing of hands, quivering voice
Atonic Cerebral Palsy
No muscle tone, floppy
