Microbiology Flashcards
How do you know it’s an anaerobe?
Gas, bad odor
Acute bacterial endocarditis
Staph aureus (attacks healthy valves)
Subacute bacterial endocarditis
Strep viridans (attacks damaged valves) Ex. Rheumatic heart disease
How do you diagnose Rheumatic fever?
At least 2 SPECC: Subcutaneous nodules Polyarthritis Erythema marginatum (red margins) Chorea (Sydenham’s) Carditis (MAT: MS > AS > TS)
Only Gram – diplococci
Neisseria
Only Gram + diplococci
Strep pneumo
Heart block infections (5)
Don’t TeLL Chaga: Diphtheria Typhoid fever (salmonella typhii) Legionella Lyme disease Chaga’s disease (Whipple’s)
IgA protease bugs (3)
Strep pneumo
H. Influenza
Neisseria catt
What do IgA protease bugs cause?
Sinusitis, otitis media, pneumonia, bronchitis
Simple Gram – bugs (2)
Simple HE:
H. Influenza
E. Coil
Atypical (no cell wall) bugs (4)
CLUMsy: Chlamydia Legionella Ureaplasma Mycoplasma
Only Gram + endotoxin
Listeria
Gram – exotoxins (2)
H. Influenza, Bordatella pertussis
Spore forming Gram + bacteria (2)
Bacillus anthracis, Clostridium botulinum
Walking pneumonia bugs
Come My Love: 0-2 mo: Chlamydia pn 10-30 yrs: Mycoplasma pn >40 yrs: Legionella pn AIDS/Premies: Pneumo carinii
Cryoglobulinemia bugs
“I AM HE”: Influenza Adenovirus Mycoplasma Hep B,C EBV
Silver stainers
HaLV-C: H. Pylori Listeria Vibrio Campylobacter
Diarrhea onset <8 hrs
CBS:
Clostridium
Bacillus
Staph aureus
Bugs with capsules
Some Silly Killers Have Pretty Nice Capsules: Strep pneumo (only gram +) Salmonella Klebsiella H. Influenza B Pseudomonas Neisseria Citrobacter
Urease + bugs
“Urease PPUNCH” Proteus Pseudomonas Ureoplasma Nocardia Cryptococcus H. Pylori
What bugs cause Monocytosis?
“STELS” Syphilis Tb EBV Listeria Salmonella
What are the Big Mama Anaerobes?
Bacteroides fragilis
Strep bovis
C. melanagosepticus
What bugs disrupt G proteins?
Pertussis: inhibits Gi
Cholera: stimulates Gs
E. Coli: stimulates Gs
What bacteria cause UTIs and prostatitis?
E. Coli
Proteus
Klebsiella
Pseudomonas
What bug is associated with cat scratch?
Bartonella henselae
What big is associated with car saliva?
Pasturella multocida
What big is associated with cat pee?
Toxoplasmosis
What big is associated with car caca (poop)?
Toxacara cati
What diseases are caused by the Ixodes Tick?
Lyme disease – bulls eye lesion
Babesiosis – hemolytic anemia
Ehrlichyosis – puncture near eye
What bugs cause hospital abscesses?
Day 1-3: Staph aureus – lots of O2
Day 4-7: Strep viridans – no enzymes
Day >7: Anaerobes – PMNs
What kind of patients do Staph and Pseudomonas like to attack?
DM
Cystic fibrosis
Burn patients
Neutropenic patients
What diseases have granulomas?
Tb Sarcoidosis Syphilis Histiocytosis X The -ellas
What diseases provide malaria protection?
Sickle cell: African Americans
G6PD: Mediterraneans
What bug causes multiple liver abscesses?
Entamoeba histolytica
What bug causes multiple cerebral abscesses?
Citrobacter
What has multiple lung aneurysms?
Osler-Weber-Rendu
What bugs cause Loeffler Syndrome?
“NASSA” Necator americanus Ancylstoma duodenale Schistosomiasis Strongyloides Ascaris lumbticoides
What is the symptom of Loeffler Syndrome?
Pulmonary eosinophilia
What is PIE syndrome?
Pulmonary Infiltrate with Eosinophilia
What diseases have PIE syndrome?
Aspergillus
Loeffler’s
Churg-Strauss
What disease does Coxsackie A cause?
Hand Foot Mouth Disease
What disease does Coxsackie B cause?
Endocarditis, DM type 1
What bugs cause meningitis?
Bacteria 0-2 mo: “baby BEL” Group B Strep E. Coli Listeria > 2 mo: Strep pneumo 10-21 yo: N. meningitidis
What are the CSF lab values for meningitis?
PMNs —> bacteria
T cell/MP —> non bacterial
Normal glucose —> viral
What does the Hep B Core Ag tell you?
Gone before patient has symptoms (2 mo)
What does Hep Core Ab tell you?
Past infection
What does Hep Surface Ag tell you?
Current infection
What does Hep Surface Ab tell you?
Vaccination has occurred
What does Hep E Ag tell you?
Transmissibility / infectivity
What does the Hep E Ab tell you?
Low transmissibility
What antibody shows current Hep A infection?
IgM
What antibody shows past Hep A infection?
IgG
What type of people does Hep E like to infect?
Pregnant women, Asians
What is associated with Staph aureus?
Cellulitis, dairy products, gold pigment, endocarditis, styes, hordeolum (on eyelid)
What is associated with Strep pyogenes?
“LINES”, ASO, hyaluronic acid capsule
What is associated with Staph epidermidis?
Central lines, VP shunts, white pigment
What is associated with Propionibacterium acnes?
Acne, progesterone —> propionic acid
What is associated with Pasteurella multicoda?
Cat/dog saliva —> cellulitis with lymphadenitis
What is associated with Staph saprophyticus?
Female UTIs, honeymooner’s cystitis
What is associated with Hemophilus aegyptus?
Swollen eyeball with pus
What is associated with Francisella tularensis?
Ulcers at rabbit or deer tick bite site (Tx: streptomycin)
What is associated with Pseudomonas aeruginosa?
Otitis externa, icthyma granulosum, loves rubber, whirlpool folliculitis, ADP ribosylates EF-2
What is associated with Streptococcus pneumoniae?
Otitis media, red bulging tympanic membrane
What is associated with Fusobacterium?
Painful mouth ulcers, gum pus, Vincent’s angina
What is associated with Strep mutans?
Dental cavities
What is associated with Strep viridans?
Subacute bacterial endocarditis, green pigment
What is associated with Strep salivarius?
Cold agglutinin test
What is associated with Strep pyogenes?
Rheumatic fever, strain 12 —> PSGN
What is associated with Group C Strep?
Pharyngitis
What is associated with Cornybacterium diptheriae?
Chinese letters, gray pseudomembrane, suffocations, ADP ribosylates EF2, heart block, Elek test
What is associated with Strep pneumonia?
Gram + diplococci, rusty sputum, IgA protease, vaccine covers 23 strains
What is associated with H. influenza?
Gram - pleomorphic rod, factors V/X, 5C-ribose capsule
B type: meningitis, epiglottitis, sepsis
What is associated with N. catarrhalis?
Loves mucus —> attacks respiratory tract
What is associated with Chlamydia psittaci?
Parakeets, parrots
What is associated with Chlamydia pneumonia?
Staccato coughing, elementary and reticulate bodies
What is associated with Mycoplasma pneumonia?
Bullous myringitis, ground glass chest X-ray, P1 protein, erythema multiforme
What is associated with Legionella pneumonia?
AC ducts, silver stains lung, CYEA, Pontiac fever, legionnaires pneumonia
What is associated with Pneumocystis carinii pneumonia?
AIDS/premies, rusty sputum, silver stains lung, inc LDH (Tx: steroids)
What is associated with Clostridium botulinum?
Canned food, honey, inhibits Ach release, respiratory failure, risus sardonicus, tennis racquet shape
What is associated with Bordetella pertussis?
Whooping cough, ADP ribosylates Gi
What is associated with Bacillus anyhracis?
Black eschar, woolsorter’s lung disease, D-Glu, boxcar like spore (Tx: ciprofloxacin)
What is associated with H. Pylori?
Duodenal ulcers
What is associated with Campylobacter jenuni?
Raw chicken and eggs, very bloody diarrhea, inactivated by gastric juice, Guillane-Barre, seagull shape
What is associated with Salmonella?
Raw chicken and eggs, turtles, rose typhoid spots, H2S, sickle cell osteomyelitis
What is associated with Clostridium perfringens?
Holiday ham and turkey, DM gas gangrene, soil/feces
What is associated with Bacillus cereus?
Fried rice, pre formed toxin
What is associated with Listeria monocytogenes?
Raw cabbage, hot dogs, spoiled milk, migrant workers —> heart block, meningitis, abortions
What is associated with Vibrio parahaemolyticus?
Raw fish
What is associated with Actinomyces?
Face fistulas, sulfur granules
What is associated with Vibrio vulnificus?
Raw oysters, cellulitis in swimmers cuts
What is associated with Shigella?
Day care outbreaks —> seizures, destroys 60s ribosome, infects M cells
What is associated with Vibrio cholera?
Rice water diarrhea, ADP ribosylates Gs
What is associated with Clostridium difficile?
Explosive diarrhea, pseudomembranous colitis
What is associated with Yersinia enterolitica?
Presents like appendicitis + Reiter’s, bloody diarrhea
What is associated with Strep bovis?
Colon cancer
What is associated with Clostridium melanagosepticus?
Colon cancer, black pigment
What is associated with ETEC?
Travelers —> rice water diarrhea
What is associated with EHEC?
Hemorrhagic —> renal failure
What is associated with EIEC?
Inflammatory —> loose stool
What is associated with EPEC?
Pathogenic —> newborn diarrhea
What is associated with E. Coli?
Raw hamburger, ADP ribosylates Gs, verotoxin, HUS
What is associated with Proteus mirabilis?
Staghorn calculus, UTI (Tx: norfloxacin)
What is associated with Klebsiella pneumonia?
Alcoholics, currant jelly sputum, UTI, lung fissures, homeless people
What is associated with Staph saprophyticus?
Young and college girls UTIs
What is associated with Enterococcus?
UTI, infective endocarditis post-GI/GU procedure, nitrate negative UTI
What is associated with N. meningitides?
DIC, pili, releases toxin in log phase
What is associated with Brucella?
Farmers/vets, spiking fever 5x/day, animal placentas
What is associated with R. rikettsii?
Ticks —> Rocky Mountain spotted fever
What is associated with R. akari?
Mites —> fleshy papules
What is associated with R. typhi?
Fleas, starts in armpit, rash
What is associated with R. prowazekii?
Lice, starts on body, rash
What is associated with R. tsutsugamushi?
Mites —> scrub typhus
What is associated with Coxiella burnetti?
Dusty barn —> Q fever
What is associated with Yersinia pestis?
Rats, fleas —> Bubonic plague
What is associated with Bartonella henselae?
Cat scratch —> single painful lymph node, silver stains
What is associated with Bacteroides fragilis?
Post op bowel abscess, grows in blood clots
What is associated with Chlamydia trachomatis?
Neonatal inturned eyelashes/cornea ulcers
What is associated with Neisseria gonorrhea?
Pili, urethritis, tenovitis, septic arthritis