Mumps

Question 1

Mumps/Rubulavirus classification & structure

Answer 1

Family: Paramyxoviridae
Genus: Rubulavirus

Enveloped NON-segmented (-)ssRNA

12 genotypes

Baltimore: V

Question 2

Mumps incubation & infectious period

Answer 2

12-25 days

2 days before to 5 days after parotitis onset

Question 3

Mumps receptor and tropism

Answer 3

Receptor - glycans on cell walls

Tropism - T cells

Question 4

Mumps clinical picture

Answer 4

Fever, IFI

Salivary gland swelling within 48 hours

Complications:

Orchitis - 5 to 10 days post parotitis
CNS - meningitis, encephalitis, deafness
Myocarditis

Question 5

Mumps diagnostics

Answer 5

RT-PCR on buccal swab/seeum

IgM develops 5 days after symptom onset & remains positive for up to 4 weeks

Question 6

Mumps PEP & IPC

Answer 6

No HNIG/MMR recommended by UKHSA

AMERICAN ACIP recommends a third dose when previously had 2 doses MMR

Exclude non-immune contacts from work/school between D12 to D25 post contact.

Question 7

Mumps R0

Answer 7

10-12 in an unvaccinated population- much lower now with vaccine coverage