Multi-system Autoimmune Disease

Question 1

SLE classification criteria

Answer 1

Malar rash (butterfly rash)
Discoid rash 
Photosensitivity
Oral ulcers
Arthritis 
Renal 
Neurological
Haematological 
Immunological

Question 2

Complications of scleroderma

Answer 2

Limited =>
Pulmonary hypertension

Diffuse =>
Pulmonary fibrosis
Renal crisis
Small bowel bacterial overgrowth

Question 3

What is scleroderma?

Answer 3

Hard, thickened areas of skin and sometimes problems with internal organs and blood vesselscaused by the immune system attacking the connective tissue under the skin and around internal organs and blood vessels

Question 4

Sjogren’s syndrome presentation

Answer 4

Dry eyes and mouth
Parotid gland enlargment
1/3 have systemic upset =>
fatigue
fever
myalgia
arthalgia

Question 5

Complications of Sjogren’s syndrome

Answer 5

Lymphoma
Neuropathy
Purpura
Interstitial lung disease
Renal tubular acidosis

Question 6

Giant cell arteritis classification criteria

Answer 6

Any 3 of:

Age at onset ≥50 years
New headache
Temporal artery tenderness/reduced pulsation
ESR≥50
Abnormal temporal biopsy

Question 7

Treatment of mild multi-system autoimmune diseases

Answer 7

Hydroxychloroquine

Question 8

Treatment of moderate multi-system autoimmune diseases

Answer 8

Azathioprine
Methotrexate
Mycophenolate

Question 9

Treatment of severe multi-system autoimmune diseases

Answer 9

Cyclophosphamide

Rituximab

Question 10

Renal components of SLE

Answer 10

Significant proteinuria

Question 11

Neurological features of SLE

Answer 11

Unexplained seizures

Psychosis

Question 12

Haematological features of SLE

Answer 12

Low WCC, platelets, lymphocytes

Haemolytic anaemia

Question 13

Immunological features of SLE

Answer 13

Anti ds-DNA
SM
ANA