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MSS - GI Exam 2 > Mucosal Immunity > Flashcards

Mucosal Immunity Flashcards

1
Q

lamina propria

A

germ free - few LP

infectious environment - many LP

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2
Q

paneth cells

A

defensins -antimicrobial peptides

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3
Q

peyers patches

A

non-encapsulated but like lymph node

T and B cell population and APCs

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4
Q

M cells

A

no microvilli

-antigen presentation to peyers patches

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5
Q

antibody of gut

A

IgA

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6
Q

innate immunity

A

goblet cells
epithelial cells
paneth cells
M cells

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7
Q

mucins

A

O-linked oligosaccharides

-secreted and membrane bound (glycocalyx)

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8
Q

NLR

A

in cytoplasm of epithelium cells

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9
Q

TLR

A

on basolateral surface

also on dendritc cells of lamina propria (low levels)

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10
Q

defensins

A

small cationic peptides
three disulfide bonds

small bowel -alpha (HD5 HD6)
-by neutrophils

colon -beta
-by epithelial cells

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11
Q

adaptive immunity

A

IgA
Th17
suppression

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12
Q

peyers patches

A

part of GALT
follicle - B cells rich (IgM and IgD)
dome region - T, B, DC, macrophages

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13
Q

M cells

A 
top of domes
flat epithelial cells
MHC class II
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14
Q

antigen capture

A

dendritic cell extends arm to lumen

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15
Q

dendritic cell sampling

A

IL-6 and TGF-B

T cells - IFN gamma and IL 17

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16
Q

FoxP3 T reg cells

A

dampen the immune response

17
Q

regulatory dendritic cells

A

DC103

18
Q

alpha4beta7

A

binds MadCAM

for homing of lymphocytes

19
Q

CCR10

A

CCL28 homing to colon and breast tissue

20
Q

CCR9

A

homing to small intestine epithelium

21
Q

RALDH

A

synthesis of retinoic acid from Vit A

22
Q

IgA

A

neutralizes bio active antigens
-secreted into gut lumen
prevents antigen uptake

inhibit adherence of bacteria to epithelial surface

23
Q

serum IgA

A

low levels

does not induce inflammation (fix complement)

24
Q

Kupffer cells

A

filter out IgA complexes with antigen bound

25
Q

T cell independent IgA class switch

A

APRIL, BAFF, TGF-beta to B cell

26
Q

poly-Ig receptor

A

transport IgA and IgM unidirectionally to lumen

27
Q

lamina propria cells

A

mostly CD4 T cells
Th17
Th2

28
Q

Th2

A

against parasites

IL-4 and IL 13

29
Q

Th17

A

colonization and protection of gut

IL-17 and IL-22

30
Q

FoxP3

A

on T reg cells

deficiency - IBS

31
Q

IBD

A

crohns - entire thickness (terminal ileum)

ulcerative colitis - colonic mucosa

32
Q

celiac disease

A

gluten sensitivity

33
Q

tumors

A

can occur in prolonged immune responses

34
Q

crohns disease

A

perianal fistulas

35
Q

overactive Th17

A

can contribute to chronic inflammation

36
Q

Reg-III-gamma

A

antibacterial lectin

37
Q

celiac disease

A

autoantibodies - anti-gliadin, transglutaminase, endomysium

histology - villous atrophy

mediate by T cells

38
Q

food allergy

A

type I hypersensitivity
IgE mediated

non-IgE - Th2 mediated

need prior exposure

treatment - epi-pen, benadryl, IV corticosteroids

MSS - GI Exam 2 (11 decks)

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