Mucosal Immunity Flashcards

1
Q

lamina propria

A

germ free - few LP

infectious environment - many LP

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2
Q

paneth cells

A

defensins -antimicrobial peptides

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3
Q

peyers patches

A

non-encapsulated but like lymph node

T and B cell population and APCs

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4
Q

M cells

A

no microvilli

-antigen presentation to peyers patches

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5
Q

antibody of gut

A

IgA

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6
Q

innate immunity

A

goblet cells
epithelial cells
paneth cells
M cells

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7
Q

mucins

A

O-linked oligosaccharides

-secreted and membrane bound (glycocalyx)

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8
Q

NLR

A

in cytoplasm of epithelium cells

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9
Q

TLR

A

on basolateral surface

also on dendritc cells of lamina propria (low levels)

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10
Q

defensins

A

small cationic peptides
three disulfide bonds

small bowel -alpha (HD5 HD6)
-by neutrophils

colon -beta
-by epithelial cells

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11
Q

adaptive immunity

A

IgA
Th17
suppression

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12
Q

peyers patches

A

part of GALT
follicle - B cells rich (IgM and IgD)
dome region - T, B, DC, macrophages

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13
Q

M cells

A
top of domes
flat epithelial cells
MHC class II
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14
Q

antigen capture

A

dendritic cell extends arm to lumen

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15
Q

dendritic cell sampling

A

IL-6 and TGF-B

T cells - IFN gamma and IL 17

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16
Q

FoxP3 T reg cells

A

dampen the immune response

17
Q

regulatory dendritic cells

18
Q

alpha4beta7

A

binds MadCAM

for homing of lymphocytes

19
Q

CCR10

A

CCL28 homing to colon and breast tissue

20
Q

CCR9

A

homing to small intestine epithelium

21
Q

RALDH

A

synthesis of retinoic acid from Vit A

22
Q

IgA

A

neutralizes bio active antigens
-secreted into gut lumen
prevents antigen uptake

inhibit adherence of bacteria to epithelial surface

23
Q

serum IgA

A

low levels

does not induce inflammation (fix complement)

24
Q

Kupffer cells

A

filter out IgA complexes with antigen bound

25
T cell independent IgA class switch
APRIL, BAFF, TGF-beta to B cell
26
poly-Ig receptor
transport IgA and IgM unidirectionally to lumen
27
lamina propria cells
mostly CD4 T cells Th17 Th2
28
Th2
against parasites | IL-4 and IL 13
29
Th17
colonization and protection of gut | IL-17 and IL-22
30
FoxP3
on T reg cells deficiency - IBS
31
IBD
crohns - entire thickness (terminal ileum) ulcerative colitis - colonic mucosa
32
celiac disease
gluten sensitivity
33
tumors
can occur in prolonged immune responses
34
crohns disease
perianal fistulas
35
overactive Th17
can contribute to chronic inflammation
36
Reg-III-gamma
antibacterial lectin
37
celiac disease
autoantibodies - anti-gliadin, transglutaminase, endomysium histology - villous atrophy mediate by T cells
38
food allergy
type I hypersensitivity IgE mediated non-IgE - Th2 mediated need prior exposure treatment - epi-pen, benadryl, IV corticosteroids