Hunger and Satiety Flashcards

1
Q

CNS hunger centers

A

arcuate nucleus of hypothalamus

satiety - VMN, PVN
hunger - lateral hypothalamus

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2
Q

inhibitory pathway

A

POMC/CART pathway
aka melanocortin

anorexigenic

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3
Q

stimulatory pathway

A

AGRP/neuropeptide Y pathway
aka NPY pathway

orexigenic

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4
Q

MC4 receptors

A

mutation linked to obesity

-involved in inhibitory pathway

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5
Q

stimulation of inhibitory pathway

A

insulin, leptin, CCK

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6
Q

AgRP

A

MC4 receptor antagonist

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7
Q

stimulation of stimulatory pathway

A

ghrelin

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8
Q

vagal control

A

vagal afferents signal satiety and decreased feeding

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9
Q

insulin

A

decreases appetite

type I diabetics - don;t have this, increased food intake

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10
Q

leptin

A

from adipose tissue
-stimulate melanocortin pathway and inhibit NPY pathway

inhibit feeding and stimulate energy usage

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11
Q

obesity

A

leptin resistance

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12
Q

CCK

A

from duodenal mucosa with lots of fat

inhibit feeding (vagal CCK1 receptors)
inhibit gastric empyting
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13
Q

peptide YY

A

released from L cells in ileum and colon

inhibit gastric emptying and seretion
promote satiety

inhibit NPY and activate POMC

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14
Q

ghrelin

A

from oxyntic cells of stomach in response to fasting

increase appetite
stimulate NPY

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15
Q

GLP-1

A

inhibit food intake

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16
Q

OXM

A

inhibit food intake

17
Q

PP

A

inhibit food intake

18
Q

childhood obesity

A

mutation of MC4 receptor

19
Q

leptin and obesity

A

high levels and resistance

20
Q

PYY and obesity

A

low serum levels

21
Q

ghrelin and obesity

A

low in obesity - does not drive hunger

increases after dieting
decreases after gastric bypass

22
Q

serotonin and NE reuptake inhibitors

A

for obesity

increase feeling of satiety

23
Q

bariartic surgery

A

jejunoileal bypass
gastric pouch
lap band