MT2 Definitions Flashcards
Pharmacokinetics
Study of how the body absorbs, distributes, metabolizes, and excretes drugs
Absorption
Process of incorporation of a drug into the bloodstream
Movement of a drug from the site of administration to the central compartment
Pinocytosis
Invagination of part of the cell membrane to form vacuoles
First pass metabolism
Phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation
Bioavailability
Fraction of unchanged drug in the systemic circulation
Reabsorption
Process of re-incorporating a drug into the bloodstream by excreting organs
Distribution
Movement of a drug from the bloodstream into:
- various tissues around the body
- the site of target tissues/cells
Apparent volume of distribution
Hypothetical volume of fluid into which a drug distributes
Perfusion-limited
Used in describing the lack or slowness of drug action due to the target organ’s low perfusion rate
Permeability-limited
Used in describing the lack or slowness of drug action due to the drug’s ability to move across the biological membrane to target organs/sites
Fick’s Law of diffusion equation.
DM/dt = D*A(Ch-Cl)
/X
Pharmacokinetics
study of the fates of drugs in the body or what the body does to the drug
Describe comparmentalization.
Each organ/tissue contains different biomolecules and cell types that could affect the distribution/retention of a drug
Drug elimination
Irreversible process of getting rid of a drug from the body. Includes excretion and metabolism
Clearance
The volume of blood cleared of drug per unit time (L/hr)