MT2 Definitions Flashcards

1
Q

Pharmacokinetics

A

Study of how the body absorbs, distributes, metabolizes, and excretes drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Absorption

A

Process of incorporation of a drug into the bloodstream

Movement of a drug from the site of administration to the central compartment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Pinocytosis

A

Invagination of part of the cell membrane to form vacuoles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

First pass metabolism

A

Phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Bioavailability

A

Fraction of unchanged drug in the systemic circulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Reabsorption

A

Process of re-incorporating a drug into the bloodstream by excreting organs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Distribution

A

Movement of a drug from the bloodstream into:

  • various tissues around the body
  • the site of target tissues/cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Apparent volume of distribution

A

Hypothetical volume of fluid into which a drug distributes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Perfusion-limited

A

Used in describing the lack or slowness of drug action due to the target organ’s low perfusion rate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Permeability-limited

A

Used in describing the lack or slowness of drug action due to the drug’s ability to move across the biological membrane to target organs/sites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Fick’s Law of diffusion equation.

A

DM/dt = D*A(Ch-Cl)

/X

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Pharmacokinetics

A

study of the fates of drugs in the body or what the body does to the drug

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Describe comparmentalization.

A

Each organ/tissue contains different biomolecules and cell types that could affect the distribution/retention of a drug

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Drug elimination

A

Irreversible process of getting rid of a drug from the body. Includes excretion and metabolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Clearance

A

The volume of blood cleared of drug per unit time (L/hr)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Drug half-life

A

Time required for the drug concentration to change (Decrease) by 50%

17
Q

Steady state

A

Condition achieved when drug elimination is equivalent to drug administration

18
Q

Aromatic oxidation

A

add OH to para position

19
Q

Aliphatic oxidation

A

add OH to end of alkyl group (primary alcohol)

20
Q

Epoxidation

A

Adding -O- group to alkene, then further into (OH)-C-C-(OH)

21
Q

Oxidative de-alkylation

A

Alkyl group is removed, hetro-atom (N, S, O) has H instead

22
Q

Oxidative de-amination

A

NH2 removed, carbon that N-previously attached to becomes C=0

23
Q

Deactivation

A

Metabolites are less active than parental molecules, or inactive

24
Q

Trans-activation

A

metabolites are as active

25
Q

Activation

A

Pro-drugs become active metabolites and responsible for the activity

26
Q

Toxification

A

Metabolites are toxic

27
Q

Drug excretion

A

Final common pathway for the elimination of drugs

28
Q

Drug interactions

A

a situation in which a substance affects the activity of a drug when they are administered together
Two types: drug/drug or drug/food
Can occur during all steps of pharmacokinetics.

29
Q

Additive effect

A

Phenomenon of drug interaction where two drugs in combination produce the sum of their effects

30
Q

potentiation

A

Interaction between two or more drugs resulting in a pharmacological response greater than the sum of individual responses to each drug

31
Q

Synergism

A

Interaction between two or more drugs causes an increase in the effects of one or both of the drugs.