Drug metabolism basic structures Flashcards
Provide the basic structure formula for Hydrolysis of an ester drug.
Refer to notes
Provide the basic structure formula for hydrolysis of an amide drug.
Refer to notes
Provide the basic structure formula for aromatic oxidation
R-Ph –> R-Ph-OH
Provide the basic structure formula for aliphatic oxidation
R-CH2-CH3 –> R-HCOH - CH3
Provide the basic structure formula for epoxidation
Refer to notes
Provide the basic structure formula for oxidative dealkylation
R - X - CH3 –> R - X - H
X = N, S, O
+ formaldehyde
Provide the basic structure formula for oxidative deamination
Drug-NH2 + O2 –> Drug-CO-R + NH3
Provide the basic structure formula for ADH of a primary alcohol
R-CH2-OH –> R-HC=0
Provide the basic structure formula for ADH of a secondary alcohol
R - CH - OH - R’ –> R - C=O - R
Provide the basic structure formula for ADH of an aldehyde
R - HC=O –> R - COOH
Provide the basic structure formula for Glucoronic acid conjugation. Provide the coenzyme name and enzyme.
R-OH or R-COOH –> R-O-GA or R - COOGA
UDP-GA
Glucoronic acid transferase
Provide the basic structure formula for Sulfation.
Provide the coenzyme name and enzyme.
R-OH or R-COOH –> R-O-SOO-OH or …
PAPS
Sulfotransferases
refer to notes for how to draw the sulfate group
Provide the basic structure formula for gluthathione conjugation.
Provide the coenzyme name and enzyme.
R=O or epox –> R-SG
Coenzyme - glutathione
Enzyme - gluatathione-S-transferase
Provide the basic structure formula for Acetylation
Provide the coenzyme name and enzyme.
R-NH2 –> RNH-C=O-CH3
Acetyl-CoA
Acetyl-transferase
Provide the basic structure formula for methylation.
Provide the coenzyme name and enzyme.
R-NH2 or R-OH or R-SH –> R-OCH3 or R-S-CH3
SAM
Methyl-transferase
