MSK DDx Flashcards
Long Bone cortically Based Metaphyseal Lesion:
Osteochondroma Non ossifying fibroma / fibroxanthoma Aneurysmal Bone Cyst Insufficiency Fracture Fatigue Fracture Osteoid osteoma Metastasis Fibrous dysplasia Adamantinoma Benign Fibrous Histiocytoma Langerhans Cell Histiocytosis Cortical FIbrous Dysplasia Cortical Chondroma.
Erlenmeyer Flask Deformity:
“Lead HOG”
- Lead poisoning
- Heamoglobinopathy: sickle cell, thalaessaemia
- osteopetrosis.
- Gaucher
“Lead CHONG”
Lead poisoning C: craniometaphyseal dysplasia H: Haemoglobinopathy - Thalaessamia - Sickle Cell Disease O: osteopetrosis N: Niemann pick disease G: Gaucher Disease.
Bone dysplasias
- Osteopetrosis
- Fibrous dysplasia
- Ollier disease
- Multiple hereditary exostoses.
Beak like osteophytes of MC heads with spade like enlargement of terminal tufts:
Acromegaly
MCP Beak like osteophytes:
CPPD (typically 2nd and 3rd)
Haemochromotosis (more joints involved)
Acromegaly (with spade like overgrowths of distal phalanges).
Paediatric cervical spine ankylosis:
Juvenile idiopathic arthritis
Klippel Feil syndrome.
Eitiologies of neuropathic / Charcot Joint:
Diabetes Syringomyelia (upper extremity) Chronic alcohol abuse Amyloid Spinal Tumours Syphilis or Leprosy
Features of Neuropathic Joint: “5 D’s”
Destruction Dislocation Debri Disorganisation no Demineralisation.
Bone features of Sarcoid:
Hands = lace like lytic lesions in middle or distal phalanges.
hands and feet:
- acro-osteolysis
- cyst-like lesions of the phalanges
- hands more commonly affected than the feet
- lace-like osteopenia
Acute or Chronic polyarthritis.
Ankle involvement especially bilateral with erythema nodosum.
Plan: CXR
Bony Sequestrum: “E-FILM”
E: eosinophilic granuloma F: fibrosarcoma I: infection (Brodie abscess) L: lymphoma (skeletal) M: malignant fibrous histiocytoma or metastasis (especially from breast carcinoma)
4 diagnostic features of Giant Cell tumour:
1) Only occur with closed epiphyses
2) Lesion must be epiphyseal / flush with the articular surface.
3) Eccentrically located
4) Sharply defined zone of transition.
GCTs dont have a sclerotic border.
Expansile lytic lesion in posterior elements of spine:
Osteoblastoma
ABC
TB
Epiphyseal Lesion: “Evil AIG Company”
E: epiphyseal: Epiphyseal equivalent bones: - Carpals, - Patella, - Greater trochanter, - Calcaneus.
E: Eosinophilic Granuloma (<30)
A: ABC (expansile) (ABC starts in metaphysis, and can extend into epiphysis once growth plates closed)
I: Infection (closed epiphysis)
G: Giant cell tumour (adult, with closed physeal plates, abutting articular surface)
C: Chondroblastoma (child, eccentric, oedema)
Clear cell chondrosarcoma
Eosinophilic Granuloma (<30yrs).
If over 40: remove ABC / Chondroblastoma / EG, and include Mets and Myeloma.
Automatics for lytic lesion regardless of other features:
Under 30yrs: - Eosinophilic granuloma - Infection Over 40yrs: - Mets - Infection.
Sclerotic lesions:
> 40yrs: Mets.
Lesions that have regressed and become sclerotic: NOF EG Solitary bone cyst ABC Chondroblastoma.
Others: Fibrous dysplasia Osteoid osteom Infection Brown tumour Giant bone island
Malignant bone tumours based on age:
1 - 30yrs: - Ewing - Osteosarcoma 30-40yrs: - Fibrosarcoma - Malignant Fibrous Histiocytoma - Malignant giant cell tumour - Primary lymphoma of bone - parosteal sarcoma > 40yrs: - Mets - Myeloma - Chondrosarcoma.
Diffuse Bony Sclerosis: “3M’S PROOF”
M:Malignancy
- Mets
- Lymphoma
- Leukaemia
M: Myelofibrosis (>50yrs, spleenomegaly, extramedullary haematopoiesis).
M: Mastocytosis (thickened small bowel folds with nodules)
S: Sickle Cell Disease (Bone infarcts, H-vertebrae, splenic autoinfarction)
P: Paget disease
R: Renal osteodystrophy (sub periosteal resorption, Rugger jersey spine)
O: Osteopetrosis (diffusely dense, bone in bone, Sandwhich spine)
O: Other:
- Sclerotic dysplasias: osteopoikilosis, melorheostaosis
- Hyperthyroididm
- Hyperparathyroidism
- Pynknodysostosis (short, hypoplastic mandible, pointed and dense chalk pencil like distal phalanges)
F: Fluorosis (ligamentous calcification).
Shortened 4th or 5th metacarpal:
Pseudo hypoparathyroidism / Pseudo-pseudo hypoparathyroidism.
Turner syndrome
Post traumatic
Post infective
Sickle cell disease with secondary infarction.
Basal cell nevus syndrome.
Paediatric Ivory Vertebrae:
Lymphoma Osteosarcoma Osteoblastoma Blastic Mets: - Neuroblastoma - Medulloblastoma - Ewing Sarcoma
Adult Ivory Vertebrae:
Osteoblastic Mets - Prostate - breast Lymphoma (Paraspinal soft tissue mass) TB Hamangioma Chordoma Paget Disease of spine (expansion of vertebral body)
H shaped vertebrae:
Sickle cell disease
- Associated splenic autoinfarction
Gaucher disease:
- Spleenomegaly.
“THIS” Hair on end appearance skull radiograph:
T: Thalaessaemia
H: Hereditary Spherocytosis
I: Iron deficiency anaemia
S: Sickle Cell disease.
Diffusely Dense Bones algorithm:
Radiographic signs of secondary Hyper-PTH:
- Renal osteodystrophy
Small calcified spleen:
- Sickle Cell disease
Spleenomegaly:
- Myelofibrosis
Predominantly axial skeleton:
- Diffuse osteoblastic Mets
Pathological fractures:
- Osteopetrosis
Others:
- Pyknodysostosis
- Mastocytosis
- Fluorosis
- Athlete.
Expansile or lytic Rib Lesion: “FAMEB:
F: fibrous dysplasia (ground glass)
A: ABC (expansile)
M: Mets / myeloma (soft tissue component)
E: Enchondroma (chondroid matrix) (EG in child)
B: Brown tumour (radiographic signs of secondary hyperPTH).
Causes of AVN:
Trauma Steroids Aspirin Sickle cell disease Collagen vascular disease Alcohol idiopathic
ON MRI assess for background Marrow signal to assess for diffuse symmetrical abnormality as in sickle cell, or just localised to area of AVN.
Bone specific AVN:
Lunate = Kienbock Navicular = Kohler disease Metatarsal head = Freiberg infraction Femoral head child = Perthes Ring apophyses spine = Scheuermann's disease Tibial tubercle = OsGood SLater Disease
Hand arthopathy distribution:
Distal: - Psoriasis - Reactive Arthritis - OA Proximal: - RA - CPPD
High Riding shoulder DDx
CPPD
RA
Torn rotator cuff
SI Joint involvement patterns:
Symmetrical = Symmetrical Letters:
- A: Ankylosing spondylitis
- I: Inflammatory bowel disease
Asymmetric = Asymmmetrical Letters:
- P: Psoriatic
- R: Reactive.
Unilateral: consider infection.
Bilteral SI joint erosions can be seen in hyper parathyroidism as subchondral resorption.
OA / degenerative disease can also cause SI joint erosions.
Vertebral Body Plana DDx: “MELT”
M: Mets / Myeloma
E: Eosinophilic Granuloma (Child)
L: Lymphoma / Leukaemia
T: Trauma / Tb.
Periostitis long bone with / without underlying bone lesion:
Trauma HPOA Venous stasis THyroid acropachy Pachydermoperiostosis
Joints that show erosions in OA:
TMJ
AC-J
SI-J
Symphysis Pubis
Syndesmophytes:
Symmetrical Marginal:
- Ankylosing spondylitis
- Inflammatory Bowel Disease
Asymmetrical Non marginal: (Arising from vertebral body)
- Psoriatic
- Reactive
Vertebral Body Focal T1 Hypointensity:
Basivertebral vein Schmorl node Bone Island Atypical haemangioma Osteomyelitis Mets
Vertebral Body Diffuse T1 hypointensity:
Hyperplastic Marrow (isointense to muscle and discs) Multiple Mets (hypointense to disc) Multiple myeloma (hypointense to disc) Lymphoma (Hypointense to disc) Sick Cell Disease (H shaped vertebrae) Renal Osteodystrophy
Pencil in Cup deformity:
Psoriasis
Scleroderma
RA
Reactive arthritis
Multiple Lytic foci in adult:
FEEMHI
F: fibrous dysplasia E: eosinophilic granuloma (<30) E: enchondroma M: metastatic disease and myeloma/Lymphoma H: hyperparathyroidism (brown tumours) I: infection
Madelung deformity:
Idiopathic Turners syndrome Ollier disease Multiple hereditary exostoses (osteochondromas) Mucopolysaccharidoses Nail-patella syndrome`
"HIT DOC" H: Hurler syndrome I: infection T: trauma D: dyschondrosteosis O: osteochondroma (multiple hereditary exostoses) C: congenital, e.g. Turner syndrome