MSK/Analgesic Rx Flashcards
Acetaminophen
(Tylenol) non-opioid, non-antiinflammatory analgesic/antipyretic
Ibuprofen
(Advil, Motrin) NSAID, analgesic, anti-inflam, antipyretic
MOA: inhibition of prostaglandin synthesis (via cyclooxygenase); prevents formation of thromboxane A2 by platelet aggregation
Aspirin
(Zorprin) NSAID, analgesic, anti-inflam, antipyretic
MOA: inhibits synthesis of prostaglandin and thromboxane (via inhibition of cyclooxygenase); inhibits platelet aggregation
Naproxen
(Aleve, Naprosyn) NSAID
MOA: inhibition of prostaglandin synthesis (via cyclooxygenase); inhibition of platelet aggregation
Celecoxib
(Celebrex) NSAID, analgesic
MOA: COX-2 inhibition that inhibits the conversion of arachidonic acid to prostaglandins but doesn’t effect formation of prostaglandins that mediate homeostasis in GI tract, kidneys and platelets catalyzed by COX-1
Diclofenac gel
NSAID
Indomethacin
NSAID
Ketorolac
NSAID
Meloxicam
NSAID
Codeine
opioid analgesic, antitussive; opioid agonist
MOA: blocks pain by binding opiate receptors in CNS; antitussive by direct action of medulla
Hydrocodone
(Zohydro ER) opioid analgesic, antitussive; opioid agonist
Oxycodone
(Oxycontin) narcotic analgesic; opioid agonist
Methadone
(Methadose) analgesic, opioid detoxification adjunct; opioid agonist
Morphine
opioid analgesic; opioid agonist
MOA: narcotic agonist-analgesic of opiate receptors; inhibits ascending pain pathways; suppresses cough by acting on medulla
Fentanyl
opioid
Buprenorphine
opioid
Tramadol
opioid
Naloxone
(Narcan) opioid antagonist; antidote
Indications: Acute opioid overdose & reducing respiratory or mental depression due to opioids
Naltrexone
(ReVia) opioid antagonist; antidote
MOA: competitive antagonist at opioid receptor sites (precipitates withdrawal sxs in opioid-dependent individuals)
Indications: Opioid dependence, adjunct to alcohol dependence
Prednisone
(Deltasone) corticosteroid; adrenal glucocorticoid
MOA: decreases inflammation by suppression of migration of PMN luekocytes and reversal of increased capillary permeability; suppresses immune system by reducing activity and volume of lymphatic system; suppresses adrenal function at high doses
Methylprednisone
(Medrol) corticosteroid; adrenal glucocorticoid
MOA: decreases inflammation by suppression of migration of PMN luekocytes and reversal of increased capillary permeability; suppresses immune system by reducing activity and volume of lymphatic system; suppresses adrenal function at high doses
Hydrocortisone
(AHydrocort) intermediate corticosteroid;
MOA: decreases inflammation by suppression of migration of PMN luekocytes and reversal of increased capillary permeability; immunosuppressive effects
Dexamethasone
corticosteroid
Prednisolone
corticosteroid
