MSD Flashcards
anterior corticospinal tract
medial
control posture, running, walking
lateral cotricospinal tract
lateral
control distal limbs
associated with goal directed mvmts
pyramidal motor system
originates in motor cortex
control of delicate muscle mvmts
extrapyramidal system
originates in basal ganglia
more crude and supportive mvmts
UMN lesion affect
UMN lesion affect extensors in upper extremities
flexors in lower extremities
UMN & LMN lesions
UMN- increased tone, hyperactive reflexes
LMN-decreased tone, hyporeflexia
myasthenia gravis
autoimmune- disrupt nerve signals to muscles
tyrosine kinase
crisis in MG
when PT is unable to swallow, clear secretion, breathe
Parkinsons
rhythmic tumors, slowness in mvmts, rigid muscles, loss of postural reflexes, diminished substancia nigra
dominant PD
formation of lewy bodies
recessive PD
mutation in gene parkin
pharm treatment of PD
dopaminergic drugs, L-dopa
bromocriptine
anticholinergic drugs
MOA inhibitor
deep brain stim
inactivating parts of the brain without destroying others
electrodes block impulses that cause tremors
huntingtons
inherited- chromosome 4
degeneration of neurons in basal ganglia
decrease in GABA & acetylcholine
treatment for Huntington’s
no cure
chlorpromazine- SM relaxant
ALS
glutamate- excitatory neurotransmitter accum to toxic concentration
environmental toxins
abnormal immune system
ALS affects motor neurons in 3 locations
LMN in spinal cord
motor nuclei in brain
UMN in cerebral cortex
treatment for ALS
anti glutamate drug- decrease accum
MS
demyelinating disease
yellow patches of myelin destruction
occur in white matter
progressive relapse
steady decline w superimposed attacks, no remission
secondary progressive
gradual neurological deterioration
with or without superimposed attacks
primary progressive
steady increase w no attacks
older pt
relapsing remitting
least disability - most common
stable course between relapses
diagnose MS
IgG high in CSF
treatment for MS
diazepam
interferons
plasmapheresis
corticosteroids
