Motor Physiology Flashcards
Stabilizes sarcolemme & prevents contraction-induced rupture
Dystrophin
Tethers myosin to Z lines (scaffholding), binds Z lines to M line
Titin
Binds actin to Z lines
Actinin, Cap2 protein
Binds Z lines to sarcolemma
Desmin
Act as a molecular ruler that sets the length of actin during assembly
Nebulin
What is the distance achieved in each cross-bridge cycle?
10 nanometers
Small motor units are recruited first before big motor units
Size principle
Multiple fiber summation
Spatial summation
Frequency summation
Temporal summation
Each contraction occurs after complete relaxation producing stronger contraction each time
Staircase (Treppe) effect
Basis for treppe effect
Ca2 accumulation, pH changes, increased temperature
Complete fusion of individual muscle contraction when Ca is all used up
Tetany