Motor Neuron Disease Flashcards
1
Q
What is MND?
A
Progressive condition affecting motor neurones, causing weakness & eventually death (ALS)
2
Q
What age does it normally present at?
A
50-70
3
Q
More common in male or female?
A
Males
4
Q
What is the prognosis?
A
Poor: rarely >3 yeats
5
Q
What is the pathology?
A
Usually sporadic, unknown cause & RFs
Protein aggregation?
6
Q
What may be some early symptoms?
A
Weakness in the ankle or leg
Trip, difficulty climbing stairs, weak grip
7
Q
How can diagnosis be confirmed?
A
Largely clinical, but
EMG to confirm denervation of muscles due to degeneration of motor neurones
8
Q
What is EMG
A
Electromyography
9
Q
What drug can prolong life by <4 months?
A
Riluzole (sodium channel blocker)
