Chronic Liver Disease Flashcards
What is CLD?
Disease process of the liver involving progressive destruction & regeneration of liver parenchyma, leading to fibrosis & cirrhosis
How long?
> 6 months
Causes
Inflammation (chronic hepatitis, cirrhosis & hepatocellular carcinoma)
What is fibrosis?
excess fibrous connective tissue, replacement of normal tissue by scar tissue
What is cirrhosis?
chronic disease of the liver marked by degeneration of cells, inflammation, and fibrous thickening of tissue. It is typically a result of alcoholism or hepatitis
What is compensated cirrhosis?
Liver can still function properly, few clinical signs
What is decompensated cirrhosis?
Abnormal liver function, overt clinical complications
what is the prognosis?
Compensated: >12 yeats
Decompensated: 2 years
What % of cardiac output constitutes the liver?
25%
What is the blood supply to the liver?
75% portal vein
25% hepatic artery
What is the porta hepatis?
Where the R & L bile duct combine to form the common hepatic duct (from the liver)
What combines to form the common bile duct?
Common hepatic duct & cystic duct
Functions of the liver: Bilirubin Albumin Lipid Bile
Conjugation & elimination of bilirubin
Albumin synthesis
Lipid metabolism
Formation of bile`
What does bile do?
Aids digestion of lipids
Functions of the liver: Clotting factors Glucose Hormone & drug Nitrogen
Synthesis of clotting factors
Gluconeogenesis
Hormone & drug inactivation
Degradation (nitrogen excretion)