Diabetes: Management Flashcards
What is drug is first line for DM2?
Metformin
How does metformin work?
Increases sensitivity to insulin & decreses glucose production in the liver
What are is the most common reason for people not tolerating metformin?
GI upset
When is metformin contraindicated?
In renal failure & AKI
How should someone take metformin?
Swallow tablets whole with a glass of water with or after food
What can help if someone is experiencing GI upset on metformin?
Changing to a modified-release preparation
What drug class is an alternative first-line treatment if metformin isn’t tolerated?
Sulphonylurea (SU)
Give 2 examples of SUs
Glicazide & glimepiride
How do SUs work?
Stimulate pancreatic insulin secretion
What are three side effects of SUs?
Hypoglycaemia
Weight gain
GI upset (usually mild & infrequent)
What are options for additional drugs (e.g. used in triple therapy)
Gliptins (DPP-4 inhibitors) Pioglitazone SGLT-2 inhibitors GLP-1 Agonist Insulin
Give two examples of gliptins (DPP-4 inhibitors)
Which one is safe in renal impairment?
Linagliptin (safe in renal impairment)
Sitagliptin
How do gliptins (DPP-4 inhibitors) work?
Increase insulin secretion and decrease glucagon secretion (so reduce glycogen breakdown)
What are 2 side effects of gliptins (DPP-4 inhibitors)?
Pancreatitis
Weight loss
How does pioglitazone work?
Preserves B cell function & reduces insulin resistance