Diabetes: Management Flashcards

1
Q

What is drug is first line for DM2?

A

Metformin

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2
Q

How does metformin work?

A

Increases sensitivity to insulin & decreses glucose production in the liver

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3
Q

What are is the most common reason for people not tolerating metformin?

A

GI upset

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4
Q

When is metformin contraindicated?

A

In renal failure & AKI

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5
Q

How should someone take metformin?

A

Swallow tablets whole with a glass of water with or after food

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6
Q

What can help if someone is experiencing GI upset on metformin?

A

Changing to a modified-release preparation

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7
Q

What drug class is an alternative first-line treatment if metformin isn’t tolerated?

A

Sulphonylurea (SU)

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8
Q

Give 2 examples of SUs

A

Glicazide & glimepiride

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9
Q

How do SUs work?

A

Stimulate pancreatic insulin secretion

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10
Q

What are three side effects of SUs?

A

Hypoglycaemia
Weight gain
GI upset (usually mild & infrequent)

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11
Q

What are options for additional drugs (e.g. used in triple therapy)

A
Gliptins (DPP-4 inhibitors)
Pioglitazone
SGLT-2 inhibitors
GLP-1 Agonist
Insulin
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12
Q

Give two examples of gliptins (DPP-4 inhibitors)

Which one is safe in renal impairment?

A

Linagliptin (safe in renal impairment)

Sitagliptin

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13
Q

How do gliptins (DPP-4 inhibitors) work?

A

Increase insulin secretion and decrease glucagon secretion (so reduce glycogen breakdown)

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14
Q

What are 2 side effects of gliptins (DPP-4 inhibitors)?

A

Pancreatitis

Weight loss

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15
Q

How does pioglitazone work?

A

Preserves B cell function & reduces insulin resistance

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16
Q

What type of cancer is pioglitazone associated with?

A

Bladder cancer

17
Q

When is pioglitazone contraindicated?

A

Heart & liver failure

Bladder cancer

18
Q

What is a side effect of pioglitazone?

A

Increased risk of long bone fractures

19
Q

How do SGLT2 inhibitors work?

A

Increase resabsorption of glucose, therefore increase glucose excretion in urine

20
Q

What are 3 SEs of SGLT2 inhibitors? (think inc glucose in wee)

A

Thrush
UTI
Weight loss

21
Q

Give two examples of SGLT2 inhibitors

A

Dapagliflozin

Canagliflozin

22
Q

Which SGLT2 inhibitor increases DKA risk?

A

Canagliflozin

23
Q

How do GLP-1 agonists work?

A

Incretin mimetics: slow gastric emptying

24
Q

How is GLP-1 delivered?

A

S/C injection

25
Q

What is a side effect of GLP-1?

A

weight loss

26
Q

When would you consider adding insulin?

A

If HbA1c still not well controlled/ Beta cell failure

27
Q

Which medications can cause weight gain?

A

Pioglitazone (due to water retention)

Sulfonlyureas

Insulin

28
Q

Which medications can cause weight loss?

hint: the ones with numbers in them

A

DPP4 inhibitors (gliptins)

SGLT2 inhibitors

GLP-1 agonists

29
Q

Which medications can cause hypos?

A

Sulfonylureas

30
Q

What should you check for in a diabetic foot exam?

A
Ulcers
Callouses (may hide ulcers)
Hammer toe (more likely to rub on shoes)
Charcot foot 
Haemosidin deposition