Motor Neuron Disease Flashcards

1
Q

Aetiologies?

A

IdiopathicViralFamilial

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2
Q

Pathology?

A

Progressive destruction of the UMN and LMN in the motor cortex, spinal cord and peripheral nerves

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3
Q

Signs and symptoms?

A

Four main patterns:ALS - lateral cortocospinal tract and anterior horn signsHand small muscle wastingBulbar/psuedobulbar palsies Primary lateral sclerosis - purely UMN signs

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4
Q

Investigations and findings?

A

Careful history and examination MRI excludatory

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5
Q

Management?

A

Palliative - MDT basedSodium channel blocker prolongs life slightly

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6
Q

Complications?

A

Prognosis bleak

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7
Q

Epidemiology?

A

M > F, 3:2

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