GI Conditions Flashcards

1
Q

Aetiology steatosis and steatohepatitis

A

Alcohol, metabolic syndrome, starvation, steroids

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2
Q

Features of steatohepatitis

A

Fatigue, malaise, RUQ pain
AST/ALT may be raised, ALT higher in NASH, AST in alcoholic
More likely to progress to cirrhosis

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3
Q

What is cirrhosis?

A

Hepatic fibrosis, nodular disorganisation, protal hypertension and ultimatley hepatic failure

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4
Q

Aetiology cirrhosis?

A

Alcohol, chronic hep B/C, NASH, NAFLD

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5
Q

Symptoms and signs cirrhosis

A

Fatigue, anorexia, nausea, weight loss, ascites, variceal haemorrhage

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6
Q

Management cirrhosis

A

Zinc supplements, cholestyramie, consider bisphosphonates

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7
Q

Complications cirrhosis

A

Hypersplenism, Vitamin deficiency, synthetic failure, anaemia, thrombocytopenia, coagulopathy, DIC, encephalopathy

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8
Q

Ascites aetiology

A

Cirrhosis, GI/ovarian cancer, lymphoma, chronic hf, nephrotic syndrome, pancreatitis

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9
Q

Management ascites

A

Low salt, spironolactone, paracentesis

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10
Q

Symptoms of primary biliary cirrhosis

A

Asymptomatic, fatigue, pruritis, RUQ pain

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11
Q

Investigations PBC

A

High ESR, Bilirubin, hyperlipidaemia, AMA, IgM, ANA

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12
Q

Management PBC

A

UDCA, DMARDS, liver transplant

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13
Q

Primary sclerosing cholangitis features

A

Autoimmune inflammatory fibrosis of extra-hepatic bile ducts
Men < 35, underlying IBD

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14
Q

PSC investigations

A

p-ANCA, IgG, IgM, USS, ERCP, MRCP

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15
Q

Management PSC

A

Liver transplant only life-prolonging treatment

Avoid alcohol

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16
Q

Features coeliac disease

A

Autoimmune inflammation triggered by gluten

17
Q

Symptoms coeliac

A

Anaemia, abdo discomfort, diarrhoea, mouth ulcers, angular stomatits

18
Q

Associations for coeliac

A

Subfertility, miscarriage, low birth weight, dermatitis herpetiformis

19
Q

Investigations coeliac

A

anti-tTGA/anti-endomysial antibodies; undetectable after 6m gluten free
Duodenal biopsy gold standard

20
Q

management coeliac

A

Gluten free diet, consider vaccinations, bisphosphonates

21
Q

Complications coeliac

A

Osteoporosis, malnutrition, hyposplenism, lactose intolerance

22
Q

Pathogens causing gastroenteritis

A

Norovirus, campylobacter, E. coli, salmonella, shigella

23
Q

Risk for GORD

A

High intra-abdominal pressure, smoking, alcohol, coffee, obesity, hiatus hernia

24
Q

Alarm symptoms GORD

A

Dysphagia, weight loss, anaemia, vomiting, age >55, FH, Melaena

25
Q

Management GORD

A

PPI for 1-2months

26
Q

Peptic ulcer causes

A

H. pylori associated, NSAIDs, smoking, alcohol, steroids, stress, bile reflux

27
Q

Symptoms peptic ulcers

A

Epigastric pain, night waking, nausea, belching, bloating

28
Q

Investigation PU

A

FBC, H.pylori testing

29
Q

Management PU

A

PPI if NSAID induced

Eradication therapy for H. pylori

30
Q

Features crohn’s disease

A

Cobblestone colon, skip lesions, granulomas, affects any part of GI tract most commonly ileum, girls aged 15-30, smoking major risk/exacerbating factor

31
Q

Symptoms crohns disease

A

diarrhoea (mucus > blood), weight loss, abdominal pain, malaise, anorexia, mouth ulcers, perianal lesions, clubbing, ankylosing spondylitis, renal stone

32
Q

Investigations crohns disease

A

ASCA, high CRP in active disease, stool culture, ileocolonoscopy

33
Q

Treatment crohns disease

A

smoking cessation, metronidazole if fistulating, PPI if gastric
Prednisolone, IV hydrocortisone, azathiprine, infliximab

34
Q

Features UC

A

Pseudopolyps, thin ulcers, crypt abscess, distal disease

35
Q

Symptoms and signs UC

A

Bloody diarrhoea, weight loss, abdo pain, tenesmus, urgency, mouth ulcers

36
Q

Investigations UC

A

p-ANCA, magnesium, albumin, sigmoidoscopy/colonoscopy

37
Q

Treatment UC

A

Mesalazine - maintenance

Surgery