More random BB SBAs Flashcards
which receptor is associated with the paroxysmal depolarising shift in epilepsy?
NMDA
Which deep brain structure is stimulated DBS in Parkinson’s?
Subthalamic nucleus
Which of the following nucleus in the basal ganglia is input to the thalamus?
Glob pallidus internal
Where are the Purkinje cells found?
Molecular layer of the cerebral cortex
What is the term used to describe when a non-noxious stimulus elicits a pain response?
Allodynia
Which type of receptor is the 5-HT3 receptor?
Ligand-gated ion
45 y/o man collapses in a shopping centre while convulsing. The paramedics arrive 12 minutes later to find him still have a seizure. What is the acute treatment they administer?
Most likely IV diazepam
What is naloxone?
Opioid antagonist
Used to block/reverse the effects of opioid drugs (good to use in opioid overdose)
Has high affinity for mu opioid receptors
Which NTs promote sleep?
GABA
Melatonin
Adenosine
Where does the superior peduncles of the cerebellum project to?
Thalamus
What is long-term potentiation and depression?
To do with memory and learning see flashcard on memory and amnesia
What receptor does memantine act on?
NMDA
What increase the incidence of subdural haemorrhages, other than age?
Anticoagulants
Long-term alcohol abuse
Dementia
CSF leak
What area is overactive in OCD?
*Amygdala (according to notes)
Answers on google drive: Orbital gyrus Head of caudate nucleus Insula ACC
NOT:
Medial PFC
Posterior caudate
What other area/s of the brain is a target for DBS in Parkinson’s?
Zona incerta
Globus pallidus internal
What is tardive dyskinesia?
involuntary, repetitive body movements - may include grimacing, sticking out the tongue, or smacking the lips.
Which drug has zero order?
Phenytoin
What is the general mode of action of benzodiazepines?
Positive allosteric modulators of GABAa
What receptor does sumatriptan bind to?
5HT1D/B
What is methadone?
Opioid substitute
What is the primary nucleus involved with cholinergic innervation of the cerebral cortex?
Nucleus Basalis of Meynert
Waves of 13-20 Hz (high frequency) but with low amplitude are indicative of what state in a person?
Normal waking
What is the most common causes of ischaemic stroke?
Thrombosis
Embolism
Systemic hypo perfusion (shock)
Cerebral venous sinus thrombosis
What is the mechanism of action of ecstasy?
Presynaptic releasing agent of 5-HT, NA, DA
Acts on the trace-amine associated receptor 1 and vesicular monoamine transporter 2
Give examples of SSRIs
Citalopram
Fluoxetine
Paroxetine
Sertraline
Give examples of selective MAOb inhibitors
Rasagiline
Selegiline
Non-selective:
Phenelzine
Tranylcypromine
Iproniazid
Which of the following drugs for schizophrenia is associated with agranulocytosis?
Clozapine
In an outpatient department, testing of which cranial nerve reflex would be most appropriate? (idk if there wad a scenario for this, it doesn’t make much sense to me…)
Corneal
Cough
Gag
Pupillary light reflex
following a major car accident, a man sustained multiple injuries…Upon arrival to the hospital, what is the first action taken in terms of management?
CT head
Resuscitation
Measure and management of ICP?
Which of the following drugs is a DOPA decarboxylase inhibitor and CANNOT cross the BBB?
Carbidopa
What brain structure comes after the hippocampus in the Paper memory circuit?
Mamillary body
What do the plaques in AD contained?
Beta amyloid
What receptor does marijuana bind to in the brain?
CB1
Which enzyme is at the site of inflammation and makes compounds that sensitise nociceptors?
COX-2 at inflammatory tissues
What fibres are involved in acupuncture?
A-delta
