More drug reactions Flashcards
Cinchonism- tinnitus, hearing/vision loss, psychosis, and cognitive impairment
Quinidine, quinine
Parkinson-like syndrome
MR. Parkinson
Metoclopramide
Reserpine
antiPsychotics
Seizures
"I BITE my tongue" Isoniazid Buproprion Imipenem/cilastatin Tramadol Enflurane
Tardive Dyskinesia
Metoclopramide, Antipsychotics
FANCONI syndrome
"CITE" Cisplatin Ifosfamide Tenofovir Expired tetracyclines
Hemorrhagic cystitis
cyclophosphamide, ifosfamide
PREVENT with mesna
Interstitial nephritis
"FuN PIPS" Furosemide NSAIDs Proton Pump Inhibitors Penicillin Sulfa drugs
Dry cough
Ace inhibitors
Pulmonary fibrosis
"My Nose Cannot Breathe Bad Air" Methotrexate Nitrofurantoin Carmustine Bleomycin Busulfan Amiodarone
Antimuscarinic effects (4)
Atropine, TCAs, H1-blockers, antipsychotics
Disulfiram-like reactions (5)
“Sorry Pals, Can’t Go Mingle”
1st gen sulfonylureas, procarbazine, cephalosporines, griseofulvin, metronidazole
Nephrotoxicity/ototoxicity
Aminoglycosides, vancomycin, loop diuretics, cisplatin, amphotericin B
Cisplatin may respond to amifostine
CYP 450 Inducers
"Chronic alcoholics STeal Phen Phens and Never Reject Greasy Carbs" Chronic alcohol St. John's Wort Phenytoin Phenobarbital NEVIRAPINE (antiviral) Rifampin Griseofulvin Carbamazepine
CYP 450 Substrates
"AT COWs" Anti-epileptics Theophyline Cyclophosphamide OCPs Warfarin
CYP 450 Inhibitors
"SICKFACES.COM GQR" Sodium valproate Isoniazid Chloramphenicol Ketoconazole Fluconazole Acute Alcohol Cimetidine Erythromycin Sulfonamides Ciprofloxacin Omeprazole Metronidazole
Grape fruit juice
Quinidine
Ritonavir