Mood Disorders Flashcards

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1
Q

Sigmund Freud - Depression and grief
Imagined loss
Oral stage

A

Thought mourners unable to resolve their grief would turn their anger from their lost loved one towards themselves
Imagined loss: Individual interprets other types of events as severe loss events (when there’s no grief)

Most likely to become depressed following a loss when needs were not or were excessively met during oral stage

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2
Q

Average age of onset of major depressive disorder (MDD)

A

Early to mid twenties
But increasingly affecting children and adolescents now too

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3
Q

Prevalence of MDD between genders

A

Rates increase through adolescence for girls but level off for boys

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4
Q

Difference of persistent depressive disorder to MDD

A

Lasts 2 years
Higher level of impairment, younger age of onset, higher comorbidity, stronger heredity, lower social support, higher stress, higher dysfunctional personality traits
Lower response to treatment

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5
Q

Typical symptoms of mania

A

Increased energy, less sleep, problems with attention, decreased judgment
Feel that they’re special in some way

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6
Q

Bipolar I disorder vs Bipolar II disorder

A

History of manic episodes w/ depressive episodes

History of hypomanic episodes w/ depressive episodes
- Harder to diagnose because less severe

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7
Q

Prevalence of bipolar disorder between boys and girls
Age of onset

A

No difference

20 years old but increasing prevalence in children

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8
Q

Cyclothymia
Rapid cycling specifier

A

Chronic but less severe bipolar disorder
2 year history of alternating hypomanic and depressive episodes

Presence of 4+ manic and/or depressive episodes in 1 year
- Can occur or be worse by antidepressant medications so mood stabilizers important

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9
Q

Seasonal affective disorder (SAD)

A

Can occur in uni-polar MDD and bipolar disorder
Recurrent depressive episodes tied to changing seasons

Nights grow longer in winter - Less melatonin decrease
- Ppl with SAD need more melatonin to wake up so lack of sunlight makes them more drowsy
More likely to be phase-delayed circadian rhythms

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10
Q

Peri-partum and post-partum disorder

A

Peri - Last month of gestation or first few months after delivery
Post - Any time after that

Risk factors: Family history of depression, history of depressive episodes, poor marital relationship, low social support, stressful life events following childbirth
- Some more sensitive to rapid changes in reproductive hormones at delivery

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11
Q

Premenstrual dysphoric disorder (PMDD)

A

Marked affective liability, irritability/anger, depressed mood/anxiety
Loss of interest in activities, lower concentration, low energy, changes in appetite/sleep, feelings of loss of control, physical symptoms
- Need 5 symptoms

SSRIs and birth control medications (containing novel prostegins) useful to suppress ovarian cyclicity

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12
Q

Sidney Blatt and David Zuroff
Dependency and self-criticism
(Depression)

A

Rely excessively on interpersonal relationships for sense of identity
- Excessively needy, fears abandonment, feeling helpless in relationships

Prone to fears of failure, self-blame, inferiority, and guilt

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13
Q

Aaron Beck
Cognitive distortions
Cognitive triad, schemas
Diathesis-stress model

A

More likely to appraise situations negatively
- All-or-nothing thinking
- Overgeneralizations
- Magnification/Catastrophizing
- Jumping to conclusions

Schemas (structures in mind) contain beliefs about the self, world, and future (cognitive triad) - More negative in depression

Negative cog schemas remain inactive in mind and act as silent vulnerability factors
- Will trigger after event related to it happens

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14
Q

Dozois and Dobson
Organization of negative and positive schemas in depression

A

Negative schemas more organized than normal
Positive schemas more diffused

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15
Q

Individuals with bipolar disorder have been shown to display preferential attention to ___ stimuli

A

Positive stimuli
- Especially cues of rewards or incentive during mania

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16
Q

Negative feedback seeking
Excessive reassurance seeking
Stress generation hypothesis

A

Tendency to actively seek out criticism and negative feedback from others consistent to their self-schema

Tendency to seek assurance about one’s worth from others regardless of whether it’s already been provided

Depressed individuals tend to contribute to stressful life events because of maladaptive interpersonal behav

17
Q

Role of serotonin transporter gene (HTT) in depression

A

Impacts reactivity to stress
- Higher rates of MDD in response to stress for s/s and s/l

18
Q

Norepinephrine
Serotonin
Dopamine
(Depression)

A

Low serotonin receptors
- Serotonin theory of depression is not true

Low norepinephrine
- Leads to bipolar and unipolar depression

Dopamine transmission linked to serotonin receptors
- Linked to regulation of reward processing and motor behav

19
Q

Hypothalamic pituitary adrenal (HPA) axis
(Depression)

A

Hippocampus inhibits HPA axis releasing cortisol by negative feedback
- Chronic stress caused by sustained release, causing permanent damage to hippocampus and killing brain cells

Support:
- HPA more reactive in females
- Depressed/traumatized adults have smaller hippocampus
- Child abuse causes cell death in hippocampus and amygdala
- Amygdala and cinngulate cortex involved in rumination

20
Q

Sleep in depression and bipolar disorder

A

Depression:
- Enter REM earlier (by serotonin receptors and norepinephrine)

BPD:
- Sleep deprivation and events disrupting sleep schedule

21
Q

Cognitive distortions
Beck’s cognitive model (diathesis-stress model)

A

1) All or nothing thinking
2) Overgeneralization
3) Magnification/Catastrophizing
4) Jumping to conclusions

Model:
1) Negative view of self
2) Negative view of future
3) Negative view of world

22
Q

Therapies to treat unipolar depression:
Cognitive behavioural therapy (CBT)
Interpersonal psychotherapy (IPT)

A

CBT:
- Emphasizes that emotional reactions are caused by thoughts about the situation

IPT:
- Focuses on disruptions that occur in person’s interpersonal world because of depression
- Caused by:
negative feedback seeking
excessive reassurance seeking
stress generation hypothesis (Person causes own problems that cause stress)