monogenic diabetes Flashcards
1
Q
what is monogenic diabetes?
A
Diabetes caused by a mutation in a single gene
2
Q
is monogenic diabetes autosomal dominant or recessive?
A
either
3
Q
what is the most common monogenic diabetes?
A
MODY
4
Q
what diabetes are a result of a defect in insulin secretion?
A
MODY
neonatal
5
Q
what condition is caused by increased insulin?
A
acanthosis nigricans
6
Q
what are the features of MODY?
A
Autosomal dominant inheritance
Non-insulin dependent diabetes
Age of onset usually before age 25
7
Q
what are the treatments for the gene defects
A
GCK MODY. No treatment required. No follow up required.
HNF1A MODY. Can transition off insulin onto low dose sulphonylureas
KCNJ11/ABCC8 NDM. Can transition off insulin onto high dose sulphonylureas
