endocrine systems and receptors Flashcards

1
Q

what is the definition of a hormone?

A

Any substance elaborated by one cell to regulate another cell. May be delivered by autocrine, paracrine, or endocrine routes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what is the general biological response of a hormone pathway?

A

an amplification of a signal transduction cascade

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

how long can the action of hormones last?

A

from seconds to days.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

which body part provides the highest level of endocrine control?

A

the hypothalamus
(the endocrine director)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what does hypothalamic control do?

A

it integrates the activities of nervous and endocrine systems through the secretion of regulatory hormones, the synthesis of hormones and direct neural control

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

can hormones have an antagonistic action?

A

yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

can hormones have complementary actions?

A

yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what are the three classes of hormones?

A

steroids
amine-derived
peptides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is an example of a steroid hormone?

A

oestrogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is an example of an amine derived hormone?

A

adrenaline/epinephrine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is an example of a peptide hormone?

A

oxytocin
ADH
insulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

are steroids hydrophobic or hydrophilic?

A

hydrophobic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

how are steroids transported?

A

in blood plasma by binding to carrier proteins (~90%).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

true or false- unbound steroids are biologically inactive

A

FALSE
biologically active

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

name a stress hormone

A

cortisol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

when steroids pass through the plasma membrane, what process do they initiate?

A

1)Activated hormone-receptor complex forms within the cell
2) The complex binds to DNA & activates specific genes, leading to Gene activation leads to production of key proteins

17
Q

are amine hormones hydrophobic or hydrophilic?

A

Hydrophilic

18
Q

are amine hormones transported unbound or bound?

A

unbound

19
Q

which type of amine hormones are bound to carrier proteins?

A

thyroid amine hormones

20
Q

where are amine hormones secreted from?

A

the thyroid and the medulla

21
Q

where is adrenaline stored until needed?

A

as vesicles in the cytoplasm

22
Q

are peptide hormones hydrophilic or hydrophobic?

A

hydrophilic

23
Q

how are peptide hormones transported?

A

unbound in blood plasma

24
Q

where are peptide hormones secreted from?

A

pituitary
parathyroid
heart
stomach
liver
kidneys

25
Q

are peptide hormones synthesized as precursor molecules?

A

yes

26
Q

where are peptide hormones stored once synthesised?

A

secretory vesicles

27
Q

what is the structure of the peptide hormone somatostatin?

A

a ring due to disulfide bonds

28
Q

what is the structure of the peptide hormone insulin?

A

2 chains held together by disulfide bonds

29
Q

what kind of hormones are insoluble in plasma?

A

steroid and thyroid hormones

30
Q

what does binding to a carrier protein lead to?

A

Facilitation of hormone transport
Increased half-life of the hormone (half life is the amount if time it takes a hormone to lose 50% of its physiological activity)
A reservoir for the hormone

31
Q

which carrier protein binds cortisol?

A

Cortisol-binding globulin (CBG)
binds in a selective manner

32
Q

which carrier protein binds thyroxine?

A

Thyroxine-binding globulin (TBG)
binds T4 selectively
also binds some T3

33
Q

which carrier protein binds testosterone and oestradiol?

A

sex steroid binding globulin (SSBG)