Biochemistry-insulin production Flashcards
what type of hormone is insulin?
Peptide Hormone
what does loss of glucose homeostasis lead to?
Hyperglycaemia
what is the blood sugar threshold for diabetes
> 7mM at fasting level
what is a healthy blood sugar level
4-6mM
In the pancreatic islet, what do beta cells secrete?
insulin
in the pancreatic islet, what do gamma cells secrete?
somatostatin
in the pancreatic islet, what do PP cells secrete?
secrete pancreatic polypeptide
what is insulin initially synthesized as?
preproinsulin (before being cleaved into insulin)
what do pancreatic alpha cells secrete
glucagon
can the brain make its own glucose?
No
what are the risks of hypoglycemia?
Danger of coma
what is the pre diabetic blood sugar range?
6-7mM
does insulin increase or decrease blood sugar levels?
decrease
what is the proportion of cells in the pancreatic islet?
Alpha: 10-20%
beta: 60-80%
gamma: about 5%
PP cells: <1%
what is the formation of insulin?
2 polypeptide chains linked by disulphide bonds
proinsulin is made up of?
3 chains (ABC)
which chains does active insulin have?
A chain and B chain
which synthetic insulin is ultra short acting?
lispro
which synthetic insulin is short acting
Regular
which synthetic insulin is intermediate acting?
NPH
which synthetic insulin is long acting?
ultralente
which synthetic insulin is ultra long acting
glargine
lispro features
– monomeric
– not antigenic
– the most rapidly acting insulin
– Injected within 15 minutes of beginning a meal
– short duration of action- must be used in
combination with longer-acting preparation for Type
1 diabetes unless used for continuous infusion
glargine features
Recombinant insulin analog that precipitates in the neutral environment of
subcutaneous tissue
– Peakless- prolonged action
– Administered as single bedtime dose
is there a suitable synthetic alternative to the beta cell?
No
through what receptor does glucose enter beta cells
GLUT 2