adrenal gland disorders Flashcards
where are the adrenal glands located?
above the kidneys
where are the hormones that regulate cortisol and androgen production produced?
hypothalamus and anterior pituitary
what regulates aldosterone?
renin-angiotensin system and plasma potassium
when is the Renin angiotensin system activated?
in response to low BP
what does renin-angiotensin system lead to?
production of angiotensin II
what is the action of cortisol upon the CNS?
Mood lability
Euphoria/psychosis
reduced libido
what is the affect of cortisol on the immune system
decreased capillary dilatation/permeability
decreased leucocyte migration
decreased macrophage activity
decreased inflammatory cytokine production
what is the action of cortisol on bone/connective tissue?
Accelerates osteoporosis
reduced Serum calcium
reduced collagen formation
reduced wound healing
what is the affect of cortisol on the metabolic system?
increase blood sugar
increase lipolysis
increase proteolysis
what is the affect of cortisol on the circulatory/renal system?
increased Cardiac output
increased BP
increased renal blood flow and GFR
what is the main principles of use of corticosteroids?
suppress inflammation
suppress immune system
replacement treatment
when are corticosteroids used?
allergic disease
inflammatory disease
malignant disease
what does addisons disease indicate?
cortisol/adrenal insufficiency
what conditions are caused by primary adrenal insufficiency?
addisons disease
congenital adrenal hyperplasia
adrenal TB/malignancy
what are the classical features of addisons disease?
Anorexia, weight loss
fatigue/lethargy
Dizziness and low BP
Abdominal pain, vomiting,
diarrhoea
Skin pigmentation
in what % of cases of addisons are autoantibodies involved?
70%
is addisons associated with other autoimmune diseases?
yes
how is addisons diagnosed?
low sodium
high postassium
short synthetic ACTH test
increased renin and low aldosterone
adrenal antibodies
how is adrenal insufficiency managed?
hydrocortisone as cortisol replacement (if unwell give via IV first)
fludrocortisone as aldosterone replacement
education
what is the treatment in adrenal crisis?
fluids (saline)
steroids IV/IM hydrocortisone
(50mg/6hrs)
IF IN DOUBT TREAT
what causes secondary adrenal insufficiency?
pituitary/hypothalamic disease tumours
exogenous steroid use (most common cause)