Module 9 Flashcards
The primary factor in women developing osteoporosis is
Declining estrogen production
Estrogen effects on osteoclasts and osteoblasts
Reduces life span of osteoclasts and lengthens lifespan of osteoblasts
Primary osteoporosis is associated with
Aging process
Secondary osteoporosis is associated with
Chronic disease, nutritional deficiency and medications
Use of prednisone greater than _ months causes increased
3, bone breakdown and decreased bone replacement
Smoking ____ risk of an osteoporotic fracture compared to non smoker
Doubles
In activity is also a factor causing
Bone loss
The chronic diseases that may cause osteoporosis
RA, diabetes, hyperthyroidism, addisons, or liver disease
Gold standard for osteoporosis
DEXA
T score measures
BMD by comparing it with young healthy women
Z score measures
BMD by comparing it with age and gender match controls
Both t score and z score are _______ measured ___ and ____ the average BMD value
Standard deviations, above and below
BMD of 2.5 ore more below the mean is indicative of
Osteoporosis
BMD of between 1 Nd 2.5 is indicative of
Osteopenia
_____ osteoporosis related fractures occur each year
1.5 million
The amount of fractures related to osteoporosis is almost ____ the amount of heart attacks and strokes
Double
__ in __ women and _ in __ men will have an osteoporosis related fracture in their lifetime
1 in 2 and 1 in 8
FRAX calculates
10 year risk factor for osteoporosis related fracture via questionnaire
The greatest amount of bone density is loss in women occurs within
The first 5 years of menopause
Only _ out of _ women with vertebral compression fracture have symptoms
1 out of 4
Multiple wedge fractures causes spine to curve known as
Gibbus or dowagers hump
Vertebral compressions fractures cause
Loss of height, distended abdomen and stooped posture, increased kyphosis that worsens over time, breathing difficulties, abdominal pain, digestive discomfort, decreased QOL, mobility and energy, pain and deterioration of physical function, increased long term morbidity and mortality
Bisphosphonates decrease
Osteoclasts activity
Three types of bisphosphonates
Alendronate (Fosamax), risedronate (actonel) and calcitonin (miacalcin)