Module 9 Flashcards
The primary factor in women developing osteoporosis is
Declining estrogen production
Estrogen effects on osteoclasts and osteoblasts
Reduces life span of osteoclasts and lengthens lifespan of osteoblasts
Primary osteoporosis is associated with
Aging process
Secondary osteoporosis is associated with
Chronic disease, nutritional deficiency and medications
Use of prednisone greater than _ months causes increased
3, bone breakdown and decreased bone replacement
Smoking ____ risk of an osteoporotic fracture compared to non smoker
Doubles
In activity is also a factor causing
Bone loss
The chronic diseases that may cause osteoporosis
RA, diabetes, hyperthyroidism, addisons, or liver disease
Gold standard for osteoporosis
DEXA
T score measures
BMD by comparing it with young healthy women
Z score measures
BMD by comparing it with age and gender match controls
Both t score and z score are _______ measured ___ and ____ the average BMD value
Standard deviations, above and below
BMD of 2.5 ore more below the mean is indicative of
Osteoporosis
BMD of between 1 Nd 2.5 is indicative of
Osteopenia
_____ osteoporosis related fractures occur each year
1.5 million
The amount of fractures related to osteoporosis is almost ____ the amount of heart attacks and strokes
Double
__ in __ women and _ in __ men will have an osteoporosis related fracture in their lifetime
1 in 2 and 1 in 8
FRAX calculates
10 year risk factor for osteoporosis related fracture via questionnaire
The greatest amount of bone density is loss in women occurs within
The first 5 years of menopause
Only _ out of _ women with vertebral compression fracture have symptoms
1 out of 4
Multiple wedge fractures causes spine to curve known as
Gibbus or dowagers hump
Vertebral compressions fractures cause
Loss of height, distended abdomen and stooped posture, increased kyphosis that worsens over time, breathing difficulties, abdominal pain, digestive discomfort, decreased QOL, mobility and energy, pain and deterioration of physical function, increased long term morbidity and mortality
Bisphosphonates decrease
Osteoclasts activity
Three types of bisphosphonates
Alendronate (Fosamax), risedronate (actonel) and calcitonin (miacalcin)
Selective estrogen receptor modulators is an ____ _____, example is
Estrogen agonist, Raloxifene (Evista)
These two procedures are used to treat patients with intractable pain who have vertebral fractures
Vertebroplasty and kyphoplasty
In vertebroplasty and kyphoplasty, ____ is injected into the ____ which ____
Methylmethacrylate, vertebral body, restores some vertebral height and stabilizes fracture
Kyphoplasty involves inserting a
Balloon tamp into the vertebral body prior to injecting the cement
Studies have shown a significant relief of pain in __% to _% in patients with compression fracture that get kyphoplasty , even 5 years later they still have pain relief
90-95
Combined resistance training protocols in one study is defined as
The combination of resistance training and high impact or weight bearing exercise
Combined resistance training protocols were effective in improving BMD in the
Femoral neck and lumbar spine
A high load exercise is
80% of 1RM
Exercise protocol to increase BMD
Weight bearing / heavy loading with few repetitions and high strain
Within ______ of stopping exercise there can be a measurable decrease in BMD
One month
Low load, high rep may lead to
Low bone mass
Osteopenia is a t score between
-1 and - 2.5
Osteomalacia is
Bone disorder caused by a failure of calcification of bone matrix
Osteomalacia is diagnosed by
Bone biopsy and blood test
Osteomalacia causes ___ of bones
Softening
Osteomalacia is a dysfunction in
Metabolizing vitamin. d
Most common cause of osteomalacia In older adults is
Vitamin d deficiency as a result of inadequate intake, lack of exposure to sun, GI malabsorption, extensive burns, chronic diarrhea, drugs such as Dilantin
Artery most effected in femoral AVN
Circumflex
Signs and symptoms of AVN
Natal gif gait pattern, groin pain radiating to pelvis knee and back,later muscle atrophy and joint mobility restriction
Paget’s disease or ___
Osteitis deformans
Paget’s disease most often effects
The pelvis, long bones, spine, ribs, sternum and cranium
Symptoms of Paget’s disease
Bone pain, joint pain or stiffness, bowing of the femur and tibia, thoracic kyphosis, enlarged head and skull deformity, fracture, gait deviations
Drug therapy options for Paget’s
Calcitonin-salmon (mialcin), NSAIDs, bisphosphonates
Arthritis is
Degeneration of articular cartilage and inflammation of synovium
OA most often occurs in
CMC joint, knee and hip
OA exercise program
Low load, prolonged stretching performed several times per day
Over __% of THA And TKA are performed in older adults with OA
70
RA is
A systemic inflammatory autoimmune disease and disabling condition