Module 2 Flashcards
What is cellular aging
When cells decrease and tissues age
Aging is a biological process that leads to what two things
Reduced tissue and physiological function and the susceptibility to diseases
How do you determine chronological age
By examining the cellular changes in the body
Senescent cells undergo three changes:
Uptake of nutrients and repair of genetic damage decreases, DNA and RNA synthesis declines, cells have morphological changes
Aged mitochondria have a
Decreased ability to survive hypoxic insult
Mitochondrial decline starts at age
50
What is sarcopenia
Loss of muscle mass
What is dynapenia
Lack of strength and power
Strength declines at a rate of _____ after 60
10-15% per decade
Muscles ____ in volume with age
Decrease
There is a ____ in the number of motor units with age
Decrease
There is a _____ in muscle fiber size with age
Decrease
There is a greater decrease in type ____ muscle fibers with age
II
With aging there is an _____ in collagen content
Increase
With increased collagen content there is:
A decrease in muscle elasticity
Due to the change in collagen content there is also infiltration of
Fat both macro and micro
Power decreases at a rate of
3-5% annually
LE Muscle ____ over muscle ___ is a greater predictor of functional limitations
Power, strength
Neuromusculoskeltal and physiologic systems peak at age
30
Decreased ability of cartilage Chondrocytes to
Restore extra cellular matrix
Slough off in cartilage _____ creates turn over and new cartilage
Horizontal
In which direction is cartilage damage worse
Vertical
What two things are bound to Proteoglycans
Glucosaminoglycans and hyaluronic acid
Proteoglycans are part of the
Extra cellular matrix
Weight bearing exercises will increase
Proteoglycan content
Loss of connective tissue elasticity and diminished fibroblast activity results in
Inadequate maintenance of collagen fibers and matrix
Amount of bone formed during remodeling phase will
Decrease
Rate of bone loss is ___% each year
1
What happens to max cardiac output and vo2 max with age
Both decrease
A decreased cardiac output causes decreased
Blood flow to the body