Module 8 Flashcards
Which side of a ferrite magnet will stimulate the neurology?
South
Which area of the brain generally requires oxygen or RNA for accurate AK testing?
Frontals
. What is the expected muscle inhibition pattern with an up or down-regulated hemisphere?
IL hip flexor and Soleus
CL shoulder extensor
Which muscles often become inhibited with an up-regulated frontal lobe?
Contralateral neck extensors
Which neurotransmitters(modulators) are commonly low with an up-regulated frontal lobe?
Serotonin and dopamine
. How does a neuromodulator differ from a neurotransmitter?
A neurotransmitter primarily affects ionotropic receptors and has a short term affect whilst
neuromodulators effect metabotropic receptors and induce a longer lasting effect which
modulates the impact of NTs and long term function of the neuron
What function does the ascending reticular activating system (ARAS) have on brain function?
Increases level of arousal/vigilance and improves noise to signal ration in the brain
Why does pyrolurria have such a profound effect on Frontal and left Temporal lobe
function?
Frontals and left Temporal lobe are associated with protein deficiencies. Pyrroluria results in decreased unfolding (digestion) of protein structures in the stomach (decreased HCL) resulting in a lower ability of proteases to break down which ultimately results in lower systemic protein levels. Pyrolurria has also been shown to be associated with lower levels of arachadonic acid.
Why is the copper:zinc ratio more important than overall zinc level?
It gives a functional interpretation of both copper and zinc metabolism whilst indicating the
level of MT function
What is the normal value for the copper to zinc ratio?
0.8 – 1.0
List 3 ways serotonin can be elevated without supplementation
Exercise
Sunlight
Burn vanilla
Why is tetrahydrobiopterin and zinc so crucial for healthy monoamine function?
Involved in all monoamine metabolism. BH4 is the rate limiting factor for monoamine
production whilst Cu:zn ratio regulates the production of serotonin, dopamine and
norepinephrine
How does histone methylation influence monoamine neurotransmitters?
Decreases production of reuptake proteins therefore increases NT activity
How does histone acetylation influence monoamine neurotransmitter function?
Increases production of reuptake proteins therefore decreases NT activity
Why must one be careful providing folate to an under-methylator?
Folates can inhibit deacetylase, increasing acetylation, which can result in lowered serotonin
levels
Sine and Square sound waves have what influence on hemispheric tone?
Sine wave stimulates hemispheric tone
Square wave inhibits hemispheric tone
List 3 ways one can assess whether a hemisphere is up-regulated or down-regulated?
North or South pole of magnet, sine or square wave, counting/singing
How do left and right hemispheres affect speech?
Left hemisphere is associated with syntax and actual word choice
Right brain is associated with emotional content and intonation
Which fats seem to help calm up-regulated brain lobes?
Frontals - DPA
Left parietal– Linoleic
Left Temporal – Arachidonic (Protein deficiency)
Right hemispheric - Linolenic
Which fats seem to help stimulate down-regulated lobes?
Frontals – Erucic
Left Parietal – DHA
Left Temporal –EPA
Right hemisphere - GLA
What are the three main categories of saturated fat?
Short, medium and long chain fatty acids
How are SCFAs produced and what is their primary function?
Produced from fermentation of dietary fibre by probiotics
These are used directly for intestinal energy
What is the influence of LCT on insulin and LDL levels?
It creates insulin resistance and elevates LDL levels
How do MCT and LCT differ in metabolism?
LCT - do not cross BBB therefore cannot be used as an energy source in the CNS
Do not enter the liver directly. They enter the lymphatic system then peripheral
tissues THEN the liver
