MODULE 6 : CONVERSION OF AMINO ACIDS TO SPECIALIZED PRODUCTS Flashcards
Becomes atoms 4, 5, and 7 of purine
GLYCINE
Amino acid source of creatine and creatinine in the liver
GLYCINE
Amino acid that constitutes the major fraction of free amino acids in plasma together with glycine
a-ALANINE
Activates myosin ATPase, chelate copper and enhace copper uptake
B-ALANYL DIPEPTIDES
Amino acid Source of spingosine which is a component of sphingomyelin
SERINE
Amino acid which is the principal source of methyl groups in the body
METHIONINE
Amino acid precursor of Nitric Oxide, a neurotransmitter, vasodilator and smooth muscle relaxant
ARGININE
Converted to epinephrine and norepinephrine in neural cells
TYROSINE
An inhibitory neurotransmitter
GAMMA AMINOBUTYRATE
Becomes atoms 4, 5, and 7 of purines
Glycine
N and alpha carbons of this AA is incorporated into pyrrole rings and methylene bridge carbons of heme
Glycine
Together with glycine, this constitutes as the major fraction of the free AA in plasma
Alpha alanine
Formed from cytosine, carnosine and anserine
Beta alanine
Phosphorylation and dephosphorylation of these residues of enzymes involved in lipid and carbohydrate metabolism
Seryl
Threonyl
Tyrosyl
Principal source of methyl groups in the body
SAM
- S adenosylmethionine
Aa that contributes its carbon skeleton for the biosynthesis of the 3-diaminopropane portions of polyamines spermine and spermidine
Methionine
Methionine contributes its carbon skeleton for the biosynthesis of the _____________ portions of polyamines spermine and spermidine
3-diaminopropane
A precursor of thioethanolamine portion of coenzyme A
Cysteine
Methionine that contributes its carbon skeleton for the biosynthesis of the 3-diaminopropane portions of polyamines _________________
Spermine and spermidine
Cysteine is a precursor of ____________ portion of coenzyme A
Thioethanolamine
Cysteine precursor of thioethanolamine portion of _____________
Coenzyme A
Precursor of the taurine that conjugates with bile acid (taurocholic acid)
Cysteine
Cysteine is a precursor of the _________ that conjugates with bile acid (taurocholic acid)
Taurine
Cysteine is a precursor of the taurine that conjugates with ____________ (taurocholic acid)
Bile acid
De carboxylation of histidine will result to?
Histamine
What catalyzes the decarboxylation of histidine to histamine?
Broad spec aromatic L amino acid decarboxylase
Formamidine donor for creatine synthesis
Arginine
_________ via ornithine produces putrescine, spermine and spermidine
Arginine
Arginine via ________ can synthesize putrescine, spermine and spermidine
Ornithine
24 hour excretion of this metabolite is proportionate to muscle mass and is a useful indicator of kidney function
Creatinine
This AA serves as a precursor of the intercellular signaling molecule NO
Arginine
These polyamines function in cell proliferation and growth
Spermine and spermidine
Spermine and spermidine
A. Polyamide
B. Polyamine
C. Neurotransmitter
B. Polyamine
Hydroxylation of tryptophan to 5-hydroxytryptophan is acted upon by what liver enzyme?
Tyrosine hydroxylase
Subsequent decarboxylation of tryptophan forms what vasoconstrictor?
Serotonin
Subsequent decarboxylation of this AA forms serotonin
Tryptophan
Kidney and liver tissue, and the bacteria, converts tryptophan to __________ then to _________
Tryptamine
Indole 3 acetate
Neural cells convert tyrosine to ______ and _______
Epinephrine
Norepinephrine
Neural cells convert __________ to epi and norepi
Tyrosine
AA that serves as a precursor of T3 and T4
Tyrosine
Decarboxylation of L-glutamate will produce what neurotransmitter?
GABA
GABA is formed from the decarboxylation of what AA?
L- glutamate
What enzyme catalyzes the decarboxylation of L- glutamate?
L-glutamate decarboxylase