MODULE 6 : AMINO ACID CATABOLISM Flashcards

0
Q

List of glucogenic amino acids

A
PYRUVATE
KETOGLUTARATE
SUCCINYL COA
FUMARATE
OXALOACETATE
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1
Q

First step in amino acid catabolism

A

REMOVAL OF AMINO NITROGEN

Except for PROLINE, HYDROXYPROLINE, LYSINE & THREONINE

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2
Q

List of ketogenic amino acids

A

ACETYL CoA

ACETOACETATE

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3
Q

Amino acids when catabolized leads to pyruvate

A
CYS
SER
ALA
GLY
THR
TRP
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4
Q

Amino acids when catabolized leads to oxaloacetate

A

ASP

ASN

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5
Q

Amino acids when catabolized leads to ketoglutarate

A
ARG
GLU
GLN
HIS
PRO
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6
Q

Amino acids when catabolized leads to fumarate

A

PHE
ASP
TYR

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7
Q

Amino acids when catabolized leads to Succinyl CoA

A

VAL
ISO
MET

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8
Q

Amino acids when catabolized leads to acety CoA / acetoacetate

A
ISO
LEU
THR
LYS
PHE
TYR
TRP
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9
Q

Failure to catabolize oxalate leads to?

A

HYPEROXALURIA

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10
Q

Alanine is catabolized to pyruvate by what process

A

TRANSAMINATION

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11
Q

Asparagine is hydrolyzed to what amino acid before it is further catabolized to oxaloacetate

A

ASPARTIC ACID

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12
Q

Amino acids used to determine folic acid deficiency

A

HISTIDINE + FIGLU (N-formiminoglutamate)

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13
Q

Enumerate first three steps on the catabolism of branched chain amino acids

A
  1. TRANSAMINATION
  2. OXIDATIVE DECARBOXYLATION
  3. DEHYDRATION
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14
Q

Active form of methionine

A

SAM

S Adenosyl L Methionine

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15
Q

Methionine is converted to ___________ which is then further converted to Succinyl Coa

A. A - ketobutyrate
B. Propionyl Coa
C. Methylmalonyl Coa

A

A. A - ketobutyrate

16
Q

Isoleucine is converted to ___________ which is then further converted to Succinyl Coa

A. A - ketobutyrate
B. Propionyl Coa
C. Methylmalonyl Coa

A

B. Propionyl Coa

17
Q

Valine is converted to ___________ which is then further converted to Succinyl Coa

A. A - ketobutyrate
B. Propionyl Coa
C. Methylmalonyl Coa

A

C. Methylmalonyl Coa

18
Q

____________ is converted to a - keyobutyrate which is then further converted to Succinyl Coa

A. Methionine
B. Isoleucine
C. Valine

A

A. Methionine

19
Q

____________ is converted to propionyl coa which is then further converted to Succinyl Coa

A. Methionine
B. Isoleucine
C. Valine

A

B. Isoleucine

20
Q

____________ is converted to methylmalonyl coa which is then further converted to Succinyl Coa

A. Methionine
B. Isoleucine
C. Valine

A

C. Valine

21
Q

What AA is degraded via the formation of Saccharopine?

A

Lysine

22
Q

Carbon atoms of side chain and aromatic ring of TRYPTOPHAN is completely degraded via what pathway?

A

Kynurenine-anthranilate pathway

23
Q

Kynurenine-anthranilate pathway is for degradation of what AA?

A. K
B. Y
C. W
D. S

A

C. W

24
Q

An iron porphyrin metalloprotein involved in the initial reaction in the degradation of tryptophan

A

Tryptophan Oxygenase

25
Q

Tryptophan oxygenase is inducible in the liver by?

A

Adrenal corticosteroid and Tryptophan

26
Q

The action of Tryptophan Oxygenase is inhibited by?

A

Nicotinic Acid Derivatives (NADPH)

27
Q

This AA is purely Ketogenic

A

Leucine

28
Q

What are the 3 branched Chain AA?

A. KYL
B. VIL
C. QRE
D. FES

A

B. V I L

29
Q

Aminoacidopathy:

Tyrosine Catabolism is impaired

A

Alkaptonuria

30
Q

Aminoacidopathy:

Alkaptonuria: what is the deficient enzyme?

A

Homogentisate oxidase

31
Q

Aminoacidopathy:

Presence of homogentisate in the urine is a character of what condition?

A

Alkaptonuria

32
Q

Aminoacidopathy:

Impaired conversion of F to Y

A

Phenylketonuria

33
Q

Classic PKU condition has a defect on what enzyme?

A. Tetrahydrobiopterin Synthase
B. Dihydrobiopterin Synthase
C. Phenylalanine Hydroxylase

A

C. Phenylalanine Hydroxylase

34
Q

Aminoacidopathy:

Results from impaired intestinal and renal transport of neutral AA including W

A

Hartnup Disease

35
Q

Aminoacidopathy:

Results from the absence of branched chain A - ketoacid dehydrogenase complex

A

MSUD