MODULE 6 : CATABOLISM OF PROTEINS & OF AMINO ACID NITROGEN

Question 0

Half life of a typical “housekeeping”enzyme in the liver

Answer 0

100H

Question 1

Half life of liver protein

Answer 1

30mins - 150H

Question 2

Half life of regulatory enzymes

Answer 2

0.5-2H

Question 3

Target some proteins for rapid degradation

Answer 3

PEST SEQUENCES

Question 4

Targets many intracellular proteins for degradation

Answer 4

UBUQUITIN

Question 5

Retards ubiquitination

Answer 5

METHIONINE & SERINE

Question 6

Accelerates ubiquitination

Answer 6

ASPARTIC ACID & ARGININE

Question 7

Observed in Teleostean Fishes which is characterized by excretion of water continuously in order to excrete ammonia

Answer 7

AMMONOTELIC

Question 8

Excrete uric acid as semisolid guano

Answer 8

URICOTELIC

Question 9

Observed in land animals such as humans which excrete nontoxic, water soluble urea

Answer 9

UREOTELIC

Question 10

Enumerate steps in biosynthesis of urea

Answer 10

1. TRANSAMINATION
2. OXIDATIVE DEAMINATION
3. AMMONIA TRANSPORT
4. REACTIONS OF THE UREA CYCLE

Question 11

Only amino acid that undergoes oxidative deamination

Answer 11

L-GLUTAMATE

Question 12

Effect of ammonia production in metabolic acidosis and alkalosis respectively

Answer 12

INCREASES, DECREASES

Question 13

First metabolic cycle discovered

Answer 13

UREA CYCLE

Question 14

Rate limiting enzyme of urea cycle

Answer 14

CARBAMOYL-P-SYNTHASE I

Question 15

An x-chromosome disease which is in the deficiency of ornithine transcarbomoylase

Answer 15

HYPERAMMONEMIA TYPE II

Question 16

Reaction which yields the second Nitrogen of urea

Answer 16

ASPARTATE&raquo_space; CITRULINE (argininosuccinate synthase)

Question 17

Results in an autosomal defect in the gene for arginase

Answer 17

HYPERARGININEMIA