module 6 Flashcards

1
Q

anthropogenic vs natural pollution

A

anthropogenic is pollution that is a result of human influence, natural is volcanos

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2
Q

two main categories for air pollution

A

particulate matter and gaseous matter

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3
Q

common food contaminant in southeast asia resulting in liver necrosis liver failure did death and liver cancer

A

aflatoxin B1

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4
Q

major air pollutants

A

particulate matter - solids or liquid drops, engine exhaust

gaseous air pollutants - carbon monoxide, hydrogen sulfide, carbon dioxide, ozone

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5
Q

sources of air pollution

A

natural air pollutants - volcanos forest wildfires dust storms

anthropogenic- heating and power, automobiles, industrial processes.

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6
Q

types of insecticides

A

organichlorine ddt they work but increasing sensitivity of neurons resulting in tremors convulsions and death
organophosphorus - absorbed through skin and leading cause of poisoning in agriculture sector.

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7
Q

organophosphorus toxicity

A

absorbed through skin very toxic to humans.

they irreversibly inhibit acetylcholinesterase which is responsible for breaking down acetylcholine in the synaptic cleft . this causes an increase in acetylcholine in nervous tissue. decreased heart rate severe difficulty breathing fecal and urinary incontinence and blurred vision and death.

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8
Q

herbicides

A

agent orange - mimicked plant growth hormones. causes uncontrollable grow
heading to death

paraquat - most widely used herbicides. highly toxic when ingested.

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9
Q

paraquat

A

one of the most widely used herbicides, highly toxic when ingested. causes cellular damage and when ingested immediate burns to the mouth and stomach. primary target is the lungs. where cellular damage results in the development of fibrous tissue that inhibits the ability to breathe. ingestion of two teaspoons can cause death due to lung damage

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10
Q

agent orange

A

mixture used in vietnam war. it mimics plant growth hormones. causing uncontrollable growth. causing deaths

binds to argo hydrocarbon receptor which is involved in the expression of many genes required for normal cellular functioning

TCDD manifests as chloracne( severe acne) impairment of liver function and cns function. increases risk of certain cancers and birth defects.

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11
Q

lead exposure sources

A

old paint
lead acid car batteries , makes lead airborne. ends up in soil
aviation fuel and gas in some countries

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12
Q

lead toxicity

A

cns - decrease. in appetite, irritability and fatigue
brain damage learning deficits and blindness

PNS - degeneration of motor nerves. loss of coordination m.

kidneys - impaires mitochondria

blood - decreases biosynthesis of heme iron, decreasing lifespan of blood cells. causes anemia.

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13
Q

mercury sources

A

found in water and air mostly fish

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14
Q

mercury toxicity

A

mercuric mercury - inhalation through vapours toxic to kidneys

methyl mercury - mercury is converted to methyl mercury by bacteria and fish in water. most toxic form of mercury. 90% is absorbed.

targets CNS enters brain binds to nerve cell proteins and leads to nerve cell death. acute toxicity is irritability numbness and tingling. vision and hearing loss tremor and paralysis. chronic is coma and death

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15
Q

treatment for mercury toxicity

A

chelating agents such as activated charcoal only for mercuric mercury prevents it from being n absorbed

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16
Q

bisphenol A BPA

A

an industrial chemical used to make hard clear plastic known as polycarbonate.

17
Q

BPA toxicity

A

bpa has estrogen like activity meaning it can burn to estrogen receptors and mimic effects of estrogen. plays a role is reproductive cancer. fertility problemss and altered brain development in infants

18
Q

ways pharmaceutics enter the environment

A

use in agriculture - antibiotics in groundwater and soil

disposal of medication - unused drugs flushed down toilets.

human prescriptions - peed out drugs cannot be fully filtered.

19
Q

major classes of pharmaceutics in the environment

A

neuroactive drugs
steroid hormones
antibiotics
antihypertensive drugs
analgesics

20
Q

cancer prevention

A

avoid excess sunlight
monitor alcohol intake
eliminate tobacco use
eat healthy
be active
get vaccinated

21
Q

classes of cancer drugs

A

alkylating agents
mitotic inhibitors
hormone to hormone antagonist
biological

22
Q

alkylating agents moa

A

bind to and interfere with DNA replication

23
Q

mitotic inhibitors

A

affect microtubule function and the formation of the mitotic spindle preventing cell division

24
Q

hormone and hormone antagonist

A

used to treat hormone sensitive tumours by supressing cell division

25
Q

biological

A

inhibit cell replication by blocking cytokines which normally control cell growth