Module 4 Flashcards
Type I hypersensitivity
Allergic reactions
Classic allergic responses to inhaled allergens and food
Allergic responses to insect stings and drugs
Anaphylactic shock
Proteins prouced by one bacterial species that kill other bacterial species
Bacteriocins
Substances that stimulate the production of fever
Pyrogen
Predominates in blood
T cells
Members of the clone that do not become plasma cells and some of the activated T cells remain in the body as
Memory cell
Takes 10-14 days for antibody production
Plasma cells die off as antigen is used up
Primary response
Efficient phagocytes
Neutrophils
Five granulocytes
Basophils Eosinophils Neutrophils Monocytes/macrophages Lymphocytes
Leukocytes that produce antibodies
B cell
Increased in number during allergies and helminth infection
Eosinophils
Type III immune complex reactions
Serum sickness
Some autoimmune diseases
Antibody secreting cell produced by a stimulated B cell
Plasma cell
Efficient clean up phagocytes
Monocytes/macrophages
Stimulated by second exposure to antigen
Plasma cells are capable of secreting antibodies immediately
Memory cells can secrete antibodies when stimulated later
Secondary response
Process of weakening pathogens
Live vaccine
Attenuated
Antibodies that neutralize toxins
Antitoxins
Made from pathogens that have been killed by heat or chemicals
Killed vaccines
Inactivated
Contain histamine
Involved in allergic and inflammatory response
Basophils
Type II Cytotoxic reactions
Blood transfusion incompatibility
Rh factor incompatibility
Myasthenia gravis
An exotoxin that has been inactivated by heat or chemicals
Can be injected safely to stimulate the production of antibodies that are capable of neutralizing the exotoxins of pathogens such as those that cause tetanus, botulism and diphtheria
Toxoids
Foreign substances that stimulate the production of specific anti bodies
Antigen
Involved in immune system
B cells T cells
Lymphocytes
Type IV delayed hypersensitivity or cell mediated immune reactions
TB and other skin tests
Mild form of psychological dependence on a drug
Drug habituation
Intradermal
Slow absorption
Harmful effects of a drug on an organism or tissue
Drug toxicity
Oral
Slow absorption
Study of the absorption distribution Biotransformation and excretion of drugs
Pharmacokinetics
Sublingual
Rapidly absorbed
Subcateneous
Absorbs slowly
Drug is converted to a less active form
Biotransformation
When one drug increases the action of another
Potentiating effect
Serum containing antibodies that neutralize toxins
Antiserum
Beneficial or harmful interaction of one drug with another drug
Drug interaction
Itching of the skin with or without a rash
Pruritus
Edema due to increased permeability of the blood capillaries
Angioedema
Intravenous
Rapid absorption
Excessive watery discharge from the nose
Rhinitis
Inability to keep the intake of a drug or substance under control
Drug dependence
Mechanism of drug action and the relationships between drug concentration and responses in the body
Pharmacodynamics
Process of creating the most accurate list possible of all medications a patient is taking
Medication reconciliation
Oral medication contraindicated in pts who
Are vomiting NPO Gastric suctioning Unconscious Unable to swallow
Buccal
Rapidly absorbed
Found on the surface of the walls of the intestines and airway in the mucous secretions
IgA
Host defenses mechanisms-ways in which the body protects itself from pathogens- can be thought of as an army consisting of how many lines of defense
Three
Which of the following is not part of the body’s first line of defense
Fever
Each of the following is considered a part of the body’s second line of defense except
Lysozyme
Which of the following is not a consequence of activation of the complement system
Repair of damaged tissue
Each of the following is a primary purpose of the inflammatory response except
To stimulate the production of opsonins
Which of the following cells is a granulocyte
Eosinophil
Exists in a person who exhibits an unusually low physiological response to a drug and who requires increases in the dosage to maintain a given therapeutic effect
Drug tolerance
Rectal
Slow absorption
Intramuscular
Rapidly absorbed
All of the following would be considered an aspect of microbial antagonism except
Production of lysozyme
Which of the following function as opsonins
A. Antibodies
B. Antigens
C. Complement fragments
D. Both A and C
Both A and C
Which of the following statements about interferons is false
Interferons are virus specific
Which of the following is not one of the four Cardinal signs or symptoms of inflammation
Loss of function
Of the following which is least likely to be involved in CMI
Antibodies
Antibodies are secreted by
Plasma cells
Humoral immunity involves all of the following except
NK cells
Immunity that develops as a result of an actual infection is called
Natural active acquired immunity
Artificial passive acquired immunity would result from
Receiving a gamma globulin injection
The vaccines that are used to protect people from diphtheria and tetanus are
Toxoids
Natural passive acquired immunity would result from
Ingesting colostrum
Which of the following statements about IgM is false
IgM is a long lived molecule
Which of the following could be an effect of type III hypersensitivity
A. Glomerulonephritis
B. Rheumatoid arthritis
C. SLE
D. All of the above
All of the above
Most likely, immunology got its start in 1890 when theses scientists discovered antibodies while developing a diphtheria antitoxin
Jonas Salk and Albert Sabin