Module 2.5 Flashcards
In previous videos we saw
-We have looked at the strucutres of triglyceriedes nd phospolipids .
-W esw that tirglycerides have three fatty acid moleucles onded to one moleucle of glhycerol .
-Triglyceride moelcules are nonpolar making them hydrophobic (AKA insoluble in water .)
WHEREAS PHOSPHOLIPS
-Two fatty acids bonded to a glycerol .
-REMEMBER –> these fatty acids are hydrophillic .
-Flycerol is also bonded toa phosphate group .
-Phosphate group is higly charges , so this part of the moleucle is polar . Menaing the PHOSPHATE goup is hydrophillic .
MEANING WHAT BREH
-phospholips have ahydrophobic region consisting of the fatty cid .
-+a hydrophillic region consisiting of the phosphte grup .
Chceck sheet , rather than drawin a phosphatee=lipie , scientsits acc raw iy out like thi .
circle with two tails .
-AS a phospholipd contain both hydrohpilic region and hyrdophobic trhio , IF WE place them inw ater they arrange themslevs like this , CHECK SHEET .
-
-the hydrophillic part of the phospholipd moelcules phosphte group can INTERACT WITH WATER .
-However ,t he hydrophobic parts in other words the FATTY ACIDS are buried int he center way from th water .
-SCIENTISTS cll this the phospholipid bilayer .
-PHOSPHOIPID bilayer is the BAISSI of ALL CELL mEMBRANES .
-Including the cell surface membrane and rhe memranes tha surround organelles , suc as lysosmes and mitochondira .
-Membranes carry out a range of functions inc ells .
One fucntion of phospholipd bilayers
-Act as BARRIERS betweent he internal contents of the cell and the external environemnt .
-OR , between the contents of n organele and cytoplasms .
-Someitmes memranes separare one part of an organelle froma nother part (we will see more detai into this when we looka t mitchodnira)/
second fucntion of phospholipid bilhyers
Mmebranes are also a locaion for chmeical eaxcctions (stages inr edpirtion )
third funciton of phospholipdi bilayer
membranes are also inovved in cell sinalling .
like we said before ,t he cell surfce membrane provides a barriwr between the cytoplasms and the ecternal enviornment of the cell .
BECAUSE the cell surfce membrane contrians a hydrophobic center and hydrohpbic moelcules such as steroid hormone can EASILY pass thorugh the cell memerane .
HOWEVER , the hydrohobic cener prevents hydrphillic water soluble moelcules frome sasily passing through /
As HYDROHPHILLIC SUBSANCES ARE POLAR AKA THEY HAVE CHARGE ,
-These substances cannot eaisly pass through the non-polar refion of the memrbane .
REMEMBER ; water moelcules can ass thorugh the cell memrbane even htough water moelcuesl re polar .
As Water moelcules are extremely smll .
-Even so , gthis tkes plce at a slow rate .
-The cell ,e,brane is based int he phospholipd bilayer , HOWEVER it contains other parts as well .
FIRST THING TO NOTIE
-Cells urfaxe memrbane contins a large number of portein moelcuels .
-Som of these portiens are onlyon one side of the memrbaine .
-Whereas oher poreins span the memrane frm onse side to the otoher .
-The cell ,e,brane is based int he phospholipd bilayer , HOWEVER it contains other parts as well . (2)
The cells urface memrbane also contains choelstrol (saw int eh videos on lpds .)
-SEE STRCUUTRE OF CHOESTROL ONS HEET .
Cholestrol moelcules hve a polar hydrophillic grouop at the end .
-This group cn effect the poar hwad gorups on the phospholipd moleucles .
*The rest f the cholesrrol moelcule is non-polar +hydophobic .
-This part of the cholestrol mopecule cana trxt the non-polar fatty acids int he phospholipds . .
-So ebcuse choelstorl interacts withphospholipids . IT increses the strenght of the cells ufrace merae .
Making the memrbane more stbale nd less liekly to et damaged .
Another unction of choelstrol .
-CholesroL ALSO REDUCES THE SIDE WAYS MOVMEMNT OF THE PHOSPHOLIPDS AND OTHER MOECLUSL ITHIN THE MERBAEN.
-Helping to cotnrol the fulididty of the memrbane .
-Preventing the memrane from becoming too fluid under wam condirons and too rigid under cool conditons .
final dfucntion of cholestrol
-by packing the spaces begtwween the phosphoipds , cholesrol helps o reduce he movemnt of warer soluble sacorss hr cells urfce memrane .
Scienitsts call the strucutre of the cell surface memrbane the FLUID MOSIC MODEL.
-Need to be able to describe wht his means .
-The word “fluid” because the phospholipd molcule cn mvoe around wit each layer .
Menang the moelcule is flexbile nd cn change shape .
-The word “mosic” as the membranes is studed with protien moelcules .
-The rrangeemtn of the poretein molcuels varies like tile in amosaic .
-Looking into detail into the porteins we find in the cell memranes
-All membanes can be divided into two different catgeories
-Intrinsi or intergal proteins .
-Extrinsic or perpherl protins .
Intrinisc porteins
are fully EMedded from onse side to the toehr .
-As they pass right thorugh the ipid bilayer . Inrinisc proteins hae hydrohphobic amino cids ont heoutside surface of hte portein .
-The h ydrohpbic aminoa cids cna interact with the hydrohllic fatty acid tils in phospholipd bilayer .
rane porteins can be divided into two categories
There are two types of intrinsic porteins . Wchi is one of them
-PROTEIN CHANNLESLS
-potein channels contain a channel running thoruhgh he center .
-This channel is lines with the hydrohpillic amino acids and filled with water moleucles .
-Protein channels allow water-soluble moelcules nd ions o diffus htourgh .
Another type of intrinsic porteins
Carruer porteins .
-These can change thier or postion to transger moelcules or ions fromo ne side of the merbane to theo hter .
IN CONTRAST TO ITNRISNC PROTEINS EXTRISNIX porteins DO NOT spn the memrbane .
-Instea are found on one side od rh wmwmenW OE OTHER .
-Someiime extrinsic protein are attached to intrinsic proteins .
Extrinisc porteins ahev a range of functions
- some play a strcutural role within the mebrne .
2.others can act as enzymes
3.some are recepros for other moelcules like hormones .
Many membrnaes protiens lso contain a carbhodhyrate moelule atached . Scientitss call these GLYCOPROTEINS .
-GLycoprotein have a range of functions within thr ell .
1.some glycoprotens allows cell to attach to echothe to form tissues such as nervous tisue.
glycoproteins (2)
-other glycoproteind play a role in the immuneytem , prsenting antigentd to vrlls .
glycoproteins (3)
-Other glycoproteins act as rece[tprs fpr hormoenes .
-Carbodhyrates can aspp e found attached to phosholipid moelcules .
-These are called GLYCOLIPIDS.
GLYCOLIPDS
-glyclipds are oftrn used when cells come into contact with rsvhother .
-glycoipids on the surfce of onne cell , csn be recognised by anothder cell
-we can deeterminr ehenever cells come into c ontact
2.glycolipds can alo act a antigrns —>determining bloood group.
diffusion box
-btir in hr vrner
-bpth dsides of the brrier contain the sme concentrtionn of gs A .
-The cocnentrationo f gas A i he ame across oth sides of of the barrie r.
-However , oe side of the brrier contins a higher concenration of a different gas (gasB).
-Bear in mind all the prticles have kinetic energy , as they are moving ranodly .
-Particles are consttntly collidign with eachother .
If we was to remove the barrier …
-we now have a higher concentration of gas b on the left hand side and a low concnetrtion of gas b on the right hand side .
-scientists call this concentration grdient.
-overtime , as particles move randomlu , the particles of gas b will spread out through the container .
-at a certain point ,t he concneration of gas B will br yhr dsmr rveryehre . THERE IS NO CONCNETRATION GRADIENT .
THE spreading of [articles is clled diffussion .
diffuion if thr net movement of partices , from an area of higher concentration to a region of lower cocnentrtion (downwn the cocnetraiton grdien t) .
meaning of net movement .
-in diffusion , mor prticles re movng in one direction than another .
-so netmovement just men overll movement .
co2 levels wthn cell
-co2 is higher on theiside than on the outside .
-we have a oxnxentrrion gradient for co2 molecules whixh diffuse from an area of high concnetraauon \9in the cell) to an area of lower ocnenctration (otuside the cell ) , .
Eventully the concentraation of co2 iwll be the same ont he outside and th einside of the cell ., EQUILLIBIRUM WILL BE REAACHED - AT EQUILIRUM , T HERE IS NO NET MOVEMNT OF PARTICLES DO DIFFUSION DOES NOT TAKE PLACE.
- key poit aout diffusion
difusion is a passive processs .
-Meaning it does not require metabolic energy to take place .
-Metbaolic enetgy means energy released by respiration .
- key point bout diffusion
As some chemicals can eeasily diffuse thorught he cell membrane while other chemcils cann;t the cel membrne is described as partilly permemable .
FCATROS AFFECING RATE OF DIFFUION (1)
Gretaer the concnetration grdient , thr greater the rate of difusion .
FCATROS AFFECING RATE OF DIFFUION 2
-AS THE CEell membrnae contains hdyorphobic center , chrged partilcles like ions will noy be bale to diffuse htourgh the memrnae
-eter meolcule alhotugh they re polar yhry cn pass htourhg as they re very small .
-contrasting ot uncharged moelcules lieke oyxgen where it candiffuse rpildy xross the membrn
FCATROS AFFECING RATE OF DIFFUION 3
size o th prticles is lso impront as wlel
-generally smaller particles will iffuse faster than lager one s.
FCATROS AFFECING RATE OF DIFFUION 4
temeprtrue
-inw rmer condtions , particles hae more kineti eegry nd diffuse at fasterrate t codler contions . (nt porblem or mammals and birds however as they maintain constn body temperature .)
FCATROS AFFECING RATE OF DIFFUION 5
Surface area
-diffusion takes plce more reaplidly if he memrne has aLARGER surface aew compared toa smlle sufrce area .
FCATROS AFFECING RATE OF DIFFUION 6
distance that diffusion tkaes palce over .
-greater the istnce ,s lwoer the rate of diffusion . explaining why CELL MEMRBANES ARE EXTREMEENT THIN .
THIN .FCATROS AFFECING RATE OF DIFFUION 7
lastly the presence of PROTEIN CHANNELA (facciliatte diffusion) , or carrrier porteins in the membrnae .
KEY we are looking at specical type of ddiffusion clled FCILITTED DFFUSION .
-not all susbtnaces diffus e across the cell memrbane at the same rate .
as the center of the cell membrane is hydorphobic due to the fatty aicd tials of the phospholipd moelcules .
-Hydrophobic susbtnaces - steroid homroes can diffuse RAPIDLY across the memrbane .
-However , hydrohphillic substnses ,s uch as ions + polar moelcules , cnnot diffuse across the memrbane .
-An excpetionto this is wtaer as ti is small.
-HYdro[hillic susbtances cannot diffue across membranes .
-This is a porblem forcells as many of thee subsagnces are required fo rporceses isnisde the cell .
-to solve this problem , cells use facillitated diffusion
-In faciliated diffusion , hydroophillic suvstances iddfuce acreoss he cell memrbne via portein moelcuels .
-These portein moelcules allow the hydrophillic susatcnes to cross the memrbae without interacting with the hdyrophobic cente rof the phospholipid bilayer .
There are two tpes of protien movlueles involed in fcilaited diffusio .
-Both of these are example iof intrinsic / integral membranes plrotiens (compelelys pan the memrane from one side to the other )