Module 12: Cannabinoids & Synthetic Cannabinoids Flashcards
CANNABINOIDS: The primary psychoactive analyte:
delta-9-THC
C
C
CANNABINOIDS: Receptor mediates neurotransmitter release:
CB1
CANNABINOIDS: Receptor involved in immunomodulation:
CB2
CANNABINOIDS: Endogenous ligands for the cannabinoid receptors:
Eicosanoids
CANNABINOIDS: Most common neurocognitive effect:
Impairment of short term memory
CANNABINOIDS: This percent of THC is bound to plasma proteins:
97-99%
*think high Vd
In what matrix in [THC] going to be higher – Serum or Blood?:
Serum
True or False: Cannabinoids have a high partition coefficient of drug into erythrocytes.
FALSE
*Think this is which [THC] is greater in serum compared to blood
One issue for Cannabinoids that needs to be addressed in all analytical steps is that:
THC binds readily to glass and plastic
Cannabinoid concentrations in whole blood are approximately _____ the concentrations in plasma:
One-half
True or False: CANNABINOIDS: Hysteresis is displayed with this drug:
True
(Defined as the retardation or lagging of an effect behind the cause of the effect)
CANNABINOIDS: 11-OH-THC -> THCCOOH :
Reduction, Hydroxylation, Sulfation, Glucuronidation, Oxidation
Oxidation
Mean THC concentrations 15 minutes after smoking were approximately _____ of peak concentrations.
60%
The Vd of THC is:
large, small, unknown, unpredictable
Large
DHHS urine cut-off for cannabinoids:
50 ng/mL
THC adsorption from solutions can be minimized with storage at a _____ pH.
Basic
Most GC/MS confirmation procedures for THC in urine use:
Alkaline hydrolysis with sodium hydroxide
After smoking marijuana THC concentrations in blood:
Slowly decline, Remain constant for several hours, Rapidly decline
Rapidly decline
CANNABINOIDS: Primary inactive metabolite:
THCCOOH
CANNABINOIDS: DRE assessment – describe HGN, Pupil Size, Blood Pressure, Heart Rate
No HGN
normal or dilated pupils
elevated BP
increased heart rate
synthetic delta-9-THC; for nausea and vomiting for chemo
Dronabinol
Mean THC concentrations 30 minutes after smoking were approximately _____ of peak concentrations.
20%
Peak THC concentrations within _____ minutes of smoking.
9
Metabolism steps of THC (3)
1) Hydroxylation of THC to THC-OH (equally as potent, short lived)
2) Oxidation of THC-OH to THC-COOH (inactive, major end product)
3) Glucuronidation of THC-COOH (increased H2O solubility)
