Module 12: Cannabinoids & Synthetic Cannabinoids

Question 1

CANNABINOIDS: The primary psychoactive analyte:

Answer 1

delta-9-THC

Question 2

CANNABINOIDS: Primary psychoactive metabolite:

Answer 2

11-OH-THC

Question 3

CANNABINOIDS: Receptor mediates neurotransmitter release:

Answer 3

CB1

Question 4

CANNABINOIDS: Receptor involved in immunomodulation:

Answer 4

CB2

Question 4

CANNABINOIDS: Endogenous ligands for the cannabinoid receptors:

Answer 4

Eicosanoids

Question 5

CANNABINOIDS: Most common neurocognitive effect:

Answer 5

Impairment of short term memory

Question 6

CANNABINOIDS: This percent of THC is bound to plasma proteins:

Answer 6

97-99%

*think high Vd

Question 7

In what matrix in [THC] going to be higher – Serum or Blood?:

Answer 7

Serum

Question 8

True or False: Cannabinoids have a high partition coefficient of drug into erythrocytes.

Answer 8

FALSE

*Think this is which [THC] is greater in serum compared to blood

Question 9

One issue for Cannabinoids that needs to be addressed in all analytical steps is that:

Answer 9

THC binds readily to glass and plastic

Question 10

Cannabinoid concentrations in whole blood are approximately _____ the concentrations in plasma:

Answer 10

One-half

Question 11

True or False: CANNABINOIDS: Hysteresis is displayed with this drug:

Answer 11

True

(Defined as the retardation or lagging of an effect behind the cause of the effect)

Question 12

CANNABINOIDS: 11-OH-THC -> THCCOOH :

Reduction, Hydroxylation, Sulfation, Glucuronidation, Oxidation

Answer 12

Oxidation

Question 13

Mean THC concentrations 15 minutes after smoking were approximately _____ of peak concentrations.

Answer 13

60%

Question 14

The Vd of THC is:

large, small, unknown, unpredictable

Answer 14

Large

Question 15

DHHS urine cut-off for cannabinoids:

Answer 15

50 ng/mL

Question 16

THC adsorption from solutions can be minimized with storage at a _____ pH.

Answer 16

Basic

Question 17

Most GC/MS confirmation procedures for THC in urine use:

Answer 17

Alkaline hydrolysis with sodium hydroxide

Question 18

After smoking marijuana THC concentrations in blood:

Slowly decline, Remain constant for several hours, Rapidly decline

Answer 18

Rapidly decline

Question 19

CANNABINOIDS: Primary inactive metabolite:

Answer 19

THCCOOH

Question 20

CANNABINOIDS: DRE assessment – describe HGN, Pupil Size, Blood Pressure, Heart Rate

Answer 20

No HGN
normal or dilated pupils
elevated BP
increased heart rate

Question 21

synthetic delta-9-THC; for nausea and vomiting for chemo

Answer 21

Dronabinol

Question 22

Mean THC concentrations 30 minutes after smoking were approximately _____ of peak concentrations.

Answer 22

20%

Question 23

Peak THC concentrations within _____ minutes of smoking.

Answer 23

9

Question 24

Metabolism steps of THC (3)

Answer 24

1) Hydroxylation of THC to THC-OH (equally as potent, short lived)
2) Oxidation of THC-OH to THC-COOH (inactive, major end product)
3) Glucuronidation of THC-COOH (increased H2O solubility)