Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

ABFT Exam > 15: Antidepressants, Antipsychotics > Flashcards

15: Antidepressants, Antipsychotics Flashcards

1
Q

Drugs with a high therapeutic index:

Slight changes in drug dosage are unlikely to produce toxicity

Slight changes in drug concentration are likely to produce toxicity

Slight changes in drug concentration are unlikely to produce toxicity

Need frequent therapeutic drug monitoring

Large changes in drug dosage are likely to produce toxicity

A

Slight changes in drug dosage are unlikely to produce toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

First drug used to treat seizure:

A

Phenobarbital

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Much of this drug’s pharmacological activity is derived from its two active metabolites, PEMA and phenobarbital:

A

Primidone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

A Novel Psychoactive Substance and the metabolite of trazodone:

A

mCPP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Major drawback of clozapine treatment:

A

Agranulocytosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Metabolism of SSRIs

A

Extensively metabolized to mostly inactive metabolites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Considered to be the most toxic complication of neuroleptic use:

A

Neuroleptic Malignant Syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

For the SSRIs, the major metabolite route for the production of active metabolites:

A

Demethylation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Associated with high-potency antipsychotic medication and is dose-related:

A

Parkinsonism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Drug-induced movement disorders:

A

Extrapyramidal Effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Used to treat absence seizures; not effective in the treatment of motor seizures:

A

Ethosuximide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

An abnormal, excessive firing of neurons in the gray matter of the brain:

A

Seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What class of drugs is Fluoxetine?

A

SSRIs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Prone to postmortem redistribution:

A

TCAs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Late elution time on a 5% phenyl-methyl silicone column:

A

Trazodone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

These drugs have a three-ring structure common to all members of this group:

A

TCAs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Serotonin Syndrome usually occurs in this time frame following taking a new drug:

A

Hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

This is an antidepressant and tobacco-addiction medication:

A

Bupropion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Although taking just one drug that increases serotonin levels can cause serotonin syndrome, this condition occurs most often when:

A

Medications are combined

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Fluorometry is a not a specific method for measuring some neuroleptic drugs because:

A

Interferences from metabolites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Death following barbiturate intoxication is often due to:

A

Respiratory Failure

18
Q

True/False:
In general, plasma concentrations of neuroleptic agents do not correlate well with clinical signs and symptoms.

A

True

19
Q

Has become the drug of choice for the treatment of myoclonic seizures and generalized absence seizures:

A

Valproic Acid

19
Q

This drug was derived from clozapine:

A

Olanzapine

20
Q

Atypical antipsychotic agents reach steady-state plasma concentrations within:

A

2 - 10 days

21
Q

A weakly acidic drug is:

Readily absorbed from the stomach into the blood

Readily absorbed from the intestine into the blood

Absorbed equally from the stomach and intestine into the blood

All of the above

None of the above

A

Readily absorbed from the stomach into the blood

22
Q

Dystonia, Tardive Dyskinesia and Akathisia are examples of what?

A

Extrapyramidal effects

22
Q

Number of Subtypes of Generalized Seizures

A

7

22
Q

Used as an adjunct therapy for partial seizures and used to treat neuropathic pain in adults:

A

Gabapentin

23
Q

When used to treat seizures, the therapeutic range is:

A

15-40 mcg/mL

24
Q

Type of seizures that involve both hemispheres of the brain:

A

Generalized seizures

25
Q

A naturally occurring mono-saccharide derived from D-fructose:

A

Topiramate

26
Q

The most common side effect associated with this anticonvulsant is a rash:

A

Lamotrigine

27
Q

AED has structural similarities to GABA:

A

Gabapentin

28
Q

Tue/False: There is considerable first-pass metabolism with most of the antidepressants.

A

True

29
Q

One significant toxic effect of this drug is aplastic anemia:

A

Carbamazepine

30
Q

Immunoassay and/or chromatography can assay virtually all drugs that require TDM with the exception of this one notable exception:

A

Lithium

31
Q

Used to treat generalized tonic-clonic and partial seizures:

A

Carbamazepine

32
Q

A prodrug used to treat generalized tonic-clonic and partial seizures:

A

Oxcarbazepine

33
Q

Its main metabolite is HPPH, which is inactive:

A

Phenytoin

34
Q

Inhibition of the reuptake of _____ or _____ is regarded as an important action for the antidepressant drugs.

A

5-HT or NE

35
Q

For major psychoses, daily doses may range up to 2400 mg.

A

Chlorpromazine

36
Q

Loxapine metabolite

A

Amoxapine

37
Q

Antidepressants:

Organic bases with low pKa

Organic bases with high pKa

Organic bases with moderate pKa

Acidic drugs with low pKa

Acidic drugs with low pKa

A

Organic bases with moderate pKa

38
Q

Its mechanism of action is to inhibit GABA transferase:

A

Vigabatrin

39
Q

Most common type of antidepressant

A

Selective serotonin reuptake inhibitors (SSRIs)

Increase serotonin in brain

Sertraline, Fluoxetine, Citalopram

40
Q

Type of antidepressant that increases serotonin and norepinephrine in the brain

A

Serotonin and norepinephrine reuptake inhibitors (SNRIs)

Desvenlafaxine, duloxteine, venlafaxine

41
Q

An older class of antidepressants that increase serotonin and norepinephrine levels in the brain. These are often reserved for treatment-resistant depression and anxiety.

A

TCAs

Clomipramine, Protriptyline, TCA confirm drugs

42
Q

The oldest antidepressants; target the brain enzyme monoamine oxidase, which helps break down neurotransmitters such as serotonin; typically used as a last resort if other types haven’t worked.

A

MAOIs
Selegiline, Moclobemide, Tranylcypromine, Isocarboxazid,
Phenelzine

43
Q

Atypical Antidepressants

A

Bupropion
Mirtazapine
Agomelatine

ABFT Exam (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions