Module 12: Buffers Flashcards

End test 4

1
Q

What are buffers?

A

Solutions that have a weak acid & its conjugate base
- or a weak base & its conjugate acid

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2
Q

What do buffers do?

A

They help resist change in pH when a strong acid/base is added to the solution

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3
Q

What is a buffer capacity?

A

(+/-)1 of buffer pH

limit before the buffer is destroyed

(limit to the amount of acid/base that can be added before buffer loses its ability to resist change)

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4
Q

Buffer capacity is _____ above or below buffer pH

A

1

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5
Q

What is the main buffering system?

A

Blood buffering system

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6
Q

What are the 3 buffering systems in the body?

A
  1. Blood
  2. Respiratory
  3. Renal
  • Bicarbonate
  • Phosphate
  • Protein
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7
Q

The ______ & _______ systems helps control the blood pH buffering system

A

repiratory
renal

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8
Q

How does the respiratory buffering system work?

A

Carbonic acid buffer system

effects CO2 blood levels

When CO2 is dissolved in blood it produces carbonic acid –> if we are having issues with breathing out or respiratory depression (holding on to too much CO2) –> buildup of CO2 –> more carbonic acid in blood –> decreased pH

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9
Q

Increasing CO2 in the blood =

A

Decreases pH

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10
Q

How does the renal buffering system work?

A

Various buffer systems to remove hydrogen ions through the kidneys

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11
Q

What is another name for the blood buffering system?

A

Bicarbonic buffering system

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12
Q

What is the blood buffering system equilibrium equation?

A

2H2O + CO2 <==> H2CO3 + H2O <==> H3O+ + HCO3-

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13
Q

What is happening during the blood buffering system?

A

Water & CO2 are producing Carbonic acid (H2CO3) & interacting w/ more water to produce H3O & bicarbonic

2H2O + CO2 <==> H2CO3 + H2O <==> H3O+ + HCO3-

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14
Q

What does Le Chatelier’s principle state?

A

When a system at equilibrium is disturbed, the system will adjust to re-establish equilibrium

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15
Q

What is Carbonic acid?

A

H2CO3

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16
Q

What is bicarb?

A

HCO3-

17
Q

If we increases CO2 in the blood buffering system, what would happen?

A

Equilibrium which shift to the right

Increase in carbonic acid = decrease in pH

18
Q

If you are adding a solute to an equilibrium equation, equilibrium shift to the ________ side.

A

opposite

19
Q

What are the 3 main components of the blood buffering system?

A
  1. CO2
  2. Carbonic acid
  3. Bicarbonic
20
Q

In a buffer, what happens if your conjugate pair goes away?

A

Buffer is destroyed

21
Q

In a buffer math problem, how do you identify the acid?

A

(+)

22
Q

What is charge controlled by?

A

pH of the solution
pKa of the drug

23
Q

T/F: ionized drugs can cross barriers

A

F

Only unionized