Mode Of Actions

Question 1

Mode of action of beta lactam

Answer 1

Bind to PBP, blocking cell wall synthesis

Question 2

Mode of action of macrolides and Lincosamides

Answer 2

Bind to 50s subunit preventing translocation of aminoacyl transfer RNA and thus protein synthesis

No peptide bond
Protein with no utility

Question 3

Mode of action Aminoglycosides

Answer 3

Binding the 30s subunit
No protein
Kills bacteria

Question 4

Mode of action Tetracycline

Answer 4

Bind to 30s ribosomes protein blocking the entry of a new aminoacyl-tRNA
Bond is reversible so bacteriostatic

Question 5

Mode of action of quinolone

Answer 5

Bind to gyrase and topoisomerase responsible for unwind the DNA
No replication

Question 6

Mode of action of rifamycin(rifampin)

Answer 6

Binds RNA polymerase, blocking the synthesis of mRNA

Question 7

Mode of action of nitroimidazol metronidazole

Answer 7

Effective against anaerobes
Damages DNA

Question 8

Mode of action of inhibitors of metabolic pathways

Answer 8

Both Prevent synthesis of folic acid

Sulphonamide
By competing with p-aminobenzoic acid

Trimethoprim
Inhibition of dihydrfolate reductase