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Microbiology > Inhibitors of Cell Wall synthesis > Flashcards

Inhibitors of Cell Wall synthesis Flashcards

1
Q

Beta lactam

A

Penicillin
Penicillin + inhibitors of beta lactamase
Cephalosporin
Carbapeneme
Monobactam

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2
Q

Glycopeptide

A

Vancomycin
Teicoplanin

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3
Q

Inhibitors of cell wall synthesis

A

Beta lactam
Glycopeptide
Fosfomycin

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4
Q

Inhibitors of protein synthesis

A

Aminoglycosides
Macrolides
Ketolides
Streptogramins
Lincosamides
Oxazolidones
Tetracyclines
Chloramphenicol

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5
Q

Inhibitors of membrane function

A

Polymyxins
Lipopeptides

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6
Q

Inhibitors of nucleic acid synthesis

A

Quinolones
Rifamycins
Nitroimidazole

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7
Q

Inhibitors of metabolic pathways

A

Sulfonamides
Trimethoprim
By inhibiting folate synthesis

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8
Q

Antibiotics against anaerobes

A

Amox/clav, metronidazole, clindamycin

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9
Q

Antibiotics against mycobacteria

A

Isoniazid
Rifampin
Ethambutol

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10
Q

Types of targets

A

Cell wall
Ribosomes (protein synthesis)
Cytoplasmic membrane (permeability)
Nucleic acid ( their synthesis)
Metabolic pathways

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11
Q

Mode of action of beta lactam

A

Bind to PBPs, blocking cell wall synthesis and producing cell lysis

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12
Q

Mode of action Macrolides and lincosamides

A

Inhibit protein translation by binding to 50S subunit

Protein with no utility, inhibits the growth

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13
Q

Mode of action of Aminoglycosides

A

Bind to 30S.
Prohibits protein synthesis
Most effective against gram-

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14
Q

Tetracycline mode of action

A

Binds to 30S. Blocks entry of a new aminoacyl-tRNA
Bacteriostatic

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15
Q

Mode of action of Quinolones

A

Inactivates gyraseand topoisomerase, response for unwinding DNA.
No replication

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16
Q

Mode of action rifamycin/rifampin

A

Blocks synthesis of messenger RNA by binding DNA polymerase
Bactericidal

17
Q

Mode of action of nitroimidazole/ metronidazole

A

Effective against anaerobes
Produce toxic compounds that damage DNA

Microbiology (12 decks)

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