MLT-125 Exam III Flashcards
the site of a gene on a chromosome
locus
one of two or more different genes that may occupy a specific locus on a chromosome
allele
possessing a pair of identical alleles
homozygous
possessing different alleles at a given gene locus
heterozygous
a trait that will be expressed in the offspring even though it is carried on only one of the homologus chromosomes
dominant
type of gene that, in the presence of a dominant allele, does not express itself; expression occurs when it is inherited in the homozygous state
recessive
a pair of genes in which neither is dominant over the other; they are both expressed
Co-dominant or Egalitarian
a gene that does not appear to produce detectable antigen; Jk, Lu, O
amorph
outward expression of gene; blood type, eye color
phenotype
an individuals actual gene makeup; total sum of genes present on the chromosome
genotype
term used in HLA testing to denote the five genes (HLA-A,B,C,D,DR) on the same chromosome
haplotype
decrease in electrical charge of RBC when it is suspended in a high ionic strength collodial medium(albumin); also decreases the repulsion of the RBCs
zeta potential
What is the ‘job’ of IgG and IgM in terms of bridging the gap between RBCs?
IgM bridges better because it is bigger and has more attachment sites than IgG
What is the temp reactivity of IgM and igG?
IgG reacts at 30-37
IgM at 4-22
What is the effect of LISS in Ag-Ab reaction?
the LISS will help the rate of association between antigen and antibody; the rate increases when lowering the ionic strength
