Miscellaneous Tumors Flashcards
List two malignant ddx for acute hemoabdomen in dogs
- mast cell tumor
2. lymphoma
List two benign ddx for acute hemoabdomen in dogs
- benign splenic nodules
2. hematoma
What is hemangiosarcoma?
a malignant neoplasm of vascular endothelium
What are the forms hemangiosarcoma can take?
- splenic (most common)
- cutaneous (second most common)
- hepatic
- right atrial
- soft tissue
What is the “double two-thirds) rule?
2/3 of dogs with splenic masses will have a malignant tumor, and 2/3 of splenic malignancies are HSA
What are some clinical signs associated with splenic HSA?
- may be no signs or sudden death; possible signs include weakness, distended abdomen, increased RR/HR, pale mucus membranes; clinical signs may ebb and flow
- 50% reported to be in DIC at presentation; 50% of those are clinical for it
What three things should be included in staging for splenic HSA? what are two others things you may or may not do?
- LABWORK
- THORACIC IMAGING
- ABDOMINAL IMAGING-liver, spleen, LNs
- +/- echocardiography
- +/- coagulation panel
What is the metastatic rate for splenic HSA?
> 90%
What is the MST for splenic HS treated with Sx + Dox-based chemo?
6 months
What is the MST for splenic HS treated with Sx + Dox-based chemo?
6 months
List two benign ddx for acute hemoabdomen in dogs
- benign splenic nodules
2. hematoma
What is hemangiosarcoma?
a malignant neoplasm of vascular endothelium
What are the forms hemangiosarcoma can take?
- splenic (most common)
- cutaneous (second most common)
- hepatic
- right atrial
- soft tissue
What is the “double two-thirds) rule?
2/3 of dogs with splenic masses will have a malignant tumor, and 2/3 of splenic malignancies are HSA
What are some clinical signs associated with splenic HSA?
- may be no signs or sudden death; possible signs include weakness, distended abdomen, increased RR/HR, pale mucus membranes; clinical signs may ebb and flow
- 50% reported to be in DIC at presentation; 50% of those are clinical for it
What three things should be included in staging for splenic HSA? what are two others things you may or may not do?
- LABWORK
- THORACIC IMAGING
- ABDOMINAL IMAGING-liver, spleen, LNs
- +/- echocardiography
- +/- coagulation panel
What is the metastatic rate for splenic HSA?
> 90%
What is the MST for splenic HS treated with Sx + Dox-based chemo?
6 months
How does the extent of cutaneous HSA affect prognosis?
Dermal: surgery may be curative-MST is 780 days with only surgery
Hypodermal: worse; similar to visceral. Surgery + adjuvant chemotherapy warranted
____% of dogs with OSA have gross metastasis at dx and _____% eventually die of metastasis
10, 90
What is osteosarcoma?
mesenchymal tumor of bone
85% of primary bone tumors are ____
osteosarcoma