Miscellaneous Drugs & Drug Interactions

Question 1

Name three commonly used dyes and contrast media

Answer 1

Methylene blue
Indigo carmine
Fluoroscein

Question 2

Methylene Blue is used for

Answer 2

evaluation of urine clearance time
to identify where ureters enter the bladder
treat methemoglobinemia

Question 3

Large doses of M. blue may cause

Answer 3

Nausea, abdominal pain, h/a, METHEMOGLOBINEMIA

Question 4

*IV bolus of M.Blue is associated with

Answer 4

TRANSIENT HYPOTENSION and False Sp02 reduction (dye changes blood color)

Question 5

Never give M.Blue

Answer 5

SQ, Intrathecally

Question 6

Indigo Carmine is used to

Answer 6

evaluate urine clearance time

to identify where ureters enter bladder

Question 7

I. Carmine is associated with

Answer 7

slight hypertension

Question 8

I. Carmine is prepared in a

Answer 8

0.8% solution in 5 mL ampules

Question 9

M. Blue is prepared in a

Answer 9

1% solution in 10 mL ampules

Question 10

Fluoroscein is used for

Answer 10

diagnostic angiography, or angioscopy of the fundus and iris vasculature

Question 11

Fluoroscein should not be

Answer 11

injected intrathecally

Question 12

Fluoroscein transiently causes skin and urine to turne

Answer 12

yellowish

Question 13

True or False, Fluroscein can cause allergic rxn

Answer 13

True

*caution in asthmatics

Question 14

The incidence of adverse drug interaction increases as the —— of concurrently administered drugs increases

Answer 14

Number

Question 15

Thiopental (pH 10.5) precipitates when mixed with

Answer 15

Opioids (pH 3-4)

Question 16

Heparin (acidic) is neutralized by

Answer 16

Protamine (basic)

Question 17

Local anesthetics mixed with —— prolongs the DOA of the LA

Answer 17

epinephrine

Question 18

Barbiturates are displaced from their protein binding site by ——- leading to an increase in the barbiturate effect

Answer 18

Contrast media

Question 19

Hepatic Cytochrome P-450 system is INDUCED by

Answer 19

Barbiturates/ Phenytoin

Question 20

** Pseudocholinesterase is inhibited by ——-, and thereby prolongs the DOA of ——-

Answer 20

Echothiphate (eye drop), Succinylcholine

Question 21

Phenobarital’s excretion is enhanced if the urine is alkalinized by

Answer 21

Sodium bicarbonate

Question 22

Alveolar elimination of volatile anesthetic agents are prolonged with what ventilatory depressant drug

Answer 22

Opioids

Question 23

Naloxone inhibits the acitivity of

Answer 23

Opioids

Question 24

*Magnesium increases the DOA of

Answer 24

Non-depolorizing muscle relaxants

Question 25

Chlorpromazine (thorazine) combined with —–, produces profound hypotension

Answer 25

halogenated agents

Question 26

Albuterol combined with ——– increase risk of dysrthythmias and hypertension

Answer 26

halogenated agents

Question 27

ANTIcholenesterases have what effect on the heart rate

Answer 27

SEVERE BRADYCARDIA

Question 28

Lidocaine can induce —– and decrease —–, and——.

Answer 28

induce and maintain anesthesia
decrease stress response during intubation
decrease MAC, if plasma levels maintained via infusion

Question 29

Isoflurane sensitize myocardium to

Answer 29

catecholamines

*epinephrine must be limited to 3.5 mcg/kg/10-minute period when given with Isoflurane

Question 30

MAO Inhibitors block metabolism of

Answer 30

Catecholamines

Nardil, Parnate, Marplan

Question 31

MOAIs should be stopped how long before surgery

Answer 31

2 weeks

Question 32

MAOIs have a synergestic effects with

Answer 32

halogenated agents, opioids, barbiturates

Question 33

What opioid is STRICTLY CONTRAINDICATED with MAOIs

Answer 33

Meperidine»>CNS excitation, hyperpyrexia, DEATH

Question 34

Tricylclc Antidepressants block reuptake of

Answer 34

Norephinephrine»»Profound Tachy, Hypertension

Elavil
Pamelor
Tofanil
Sinequan

Question 35

TCA should be continued until

Answer 35

the day of surgery

Question 36

** Pancuronium and cause ——when given with TCA

Answer 36

DYSRHYTHMIAS

Question 37

Cimetidine inhibits

Answer 37

P-450 system

Question 38

Cimetidine —-hepatic blood flow

Answer 38

decreases and thereby decreases the rate of biotransformation

Question 39

Acute alcohol intoxication ——-MAC

Answer 39

decreases

Question 40

Chronic alcohol abuse——MAC

Answer 40

increases

Question 41

Cocaine ——-reuptake of ——

Answer 41

Inhibits, reuptake of norepinephrine

Question 42

Key treatment goal of patient on cocaine

Answer 42

Avoid SNS stimulation due to exaggerated responses that can be life threatening.

Question 43

What NMBA should be avoid in cocaine users

Answer 43

Pancuronium

Question 44

All halogenated agents produce what effect of the heart

Answer 44

Myocardial depression