Chemotherapy drugs-TARGETED anticancer drugs Flashcards
Name the seven classes of targeted anticancer drugs
Corticosteroids Sex Hormone Agonists & Antagonists GnRh agonist & Antagonists Aromatase inhibitors Tyrosine Kinase inhibitors Angiogenesis inhibitors Proteasome inhibitors
Name a corticosteroid used to treat tumors
Prednisone
Prednisone is used to induce remission in which patients
those with Acute lymphocytic Leukemia
What does prednisone do to lymphocytes
Destroys them
What are the AE of prednisone
Pancreatitis
Immunosuppression
GI ulcers
Name a sex hormone agonist used to tx CA
Estrogen
What WERE the main cancers treated with estrogens
Prostate CA
What is the MOA of estrogen for the tx of prostate CA
Inhibits the growth of prostate tissue by blocking LH
Name an estrogen antagonist used to tx CA
Tamoxifen
Tamoxifen is used to treat what specific form of CA
breast CA
*First line therapy
Tamoxifen is classifed as a
SERM
What are the AE associated with Tamoxifen
Chemically induced menopause
THROMBOEMBOLIC disease
Name the GnRH agonists used to tx CA
Leuprolide
How does Leuprolide work
Binds to the GnRH receptor in the pituitary causing densensitization which results in inhibition of release of FSH and LH thereby reducing androgen and estrogen synthesis
*considered a chemical castration
Name a GnRH antagonist
Abarelix
How does Abarelix work
Blocks pituitary responsiveness to GnRH
*doesn’t possess the “flare phenomenon” as the GnRH agonist
Name an Aramatase inhibitor
Anastrozole
What class of drug does anastrozole fall under
Imidazoles
How does Anastrozole work
It selectively inhibits aromatase which results in less conversion of androgen to estrogen
What specific form of CA is Anastrozole used to tx
Breast CA
What are the AE associated with anastrozole
Thromboembolism
Fractures
Cataracts
Endometrial CA
Name a Tyrosine Kinase inhibitor
Imatinib (Gleevec)
What form of CA does Imatinib (Gleevec) prevent
Chronic Myelogenous Leukemia
Name a Angiogenesis Inhibitor
Bevacizumab (avastin)
What specific forms of CA is Bevacizumab used to tx
colorectal CA
non-small cell lung CA
Name a Proteosome Inhihibitor
Bortezomib
How does Bortezomib work
by inhibiting 26S proteasome responsible for cell growth
What type of CA is Bortezomib used to tx
Multiple Myeloma
What are AE associated with Bortezomib
Flu-like symptoms
