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Pharmacology > Chemotherapy drugs-TARGETED anticancer drugs > Flashcards

Chemotherapy drugs-TARGETED anticancer drugs Flashcards

1
Q

Name the seven classes of targeted anticancer drugs

A 
Corticosteroids
Sex Hormone Agonists & Antagonists
GnRh agonist & Antagonists
Aromatase inhibitors
Tyrosine Kinase inhibitors
Angiogenesis inhibitors
Proteasome inhibitors
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2
Q

Name a corticosteroid used to treat tumors

A

Prednisone

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3
Q

Prednisone is used to induce remission in which patients

A

those with Acute lymphocytic Leukemia

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4
Q

What does prednisone do to lymphocytes

A

Destroys them

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5
Q

What are the AE of prednisone

A

Pancreatitis
Immunosuppression
GI ulcers

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6
Q

Name a sex hormone agonist used to tx CA

A

Estrogen

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7
Q

What WERE the main cancers treated with estrogens

A

Prostate CA

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8
Q

What is the MOA of estrogen for the tx of prostate CA

A

Inhibits the growth of prostate tissue by blocking LH

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9
Q

Name an estrogen antagonist used to tx CA

A

Tamoxifen

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10
Q

Tamoxifen is used to treat what specific form of CA

A

breast CA

*First line therapy

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11
Q

Tamoxifen is classifed as a

A

SERM

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12
Q

What are the AE associated with Tamoxifen

A

Chemically induced menopause

THROMBOEMBOLIC disease

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13
Q

Name the GnRH agonists used to tx CA

A

Leuprolide

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14
Q

How does Leuprolide work

A

Binds to the GnRH receptor in the pituitary causing densensitization which results in inhibition of release of FSH and LH thereby reducing androgen and estrogen synthesis

*considered a chemical castration

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15
Q

Name a GnRH antagonist

A

Abarelix

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16
Q

How does Abarelix work

A

Blocks pituitary responsiveness to GnRH

*doesn’t possess the “flare phenomenon” as the GnRH agonist

17
Q

Name an Aramatase inhibitor

A

Anastrozole

18
Q

What class of drug does anastrozole fall under

A

Imidazoles

19
Q

How does Anastrozole work

A

It selectively inhibits aromatase which results in less conversion of androgen to estrogen

20
Q

What specific form of CA is Anastrozole used to tx

A

Breast CA

21
Q

What are the AE associated with anastrozole

A

Thromboembolism
Fractures
Cataracts
Endometrial CA

22
Q

Name a Tyrosine Kinase inhibitor

A

Imatinib (Gleevec)

23
Q

What form of CA does Imatinib (Gleevec) prevent

A

Chronic Myelogenous Leukemia

24
Q

Name a Angiogenesis Inhibitor

A

Bevacizumab (avastin)

25
Q

What specific forms of CA is Bevacizumab used to tx

A

colorectal CA

non-small cell lung CA

26
Q

Name a Proteosome Inhihibitor

A

Bortezomib

27
Q

How does Bortezomib work

A

by inhibiting 26S proteasome responsible for cell growth

28
Q

What type of CA is Bortezomib used to tx

A

Multiple Myeloma

29
Q

What are AE associated with Bortezomib

A

Flu-like symptoms

Pharmacology (27 decks)

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