Chemotherapy drugs-TRADITIONAL anticancer tx

Question 1

Name the common traditional anticancer drug class

Answer 1

Alkylating agents
Antimetabolites
Anticancer antibiotics
Platinum Coordination complexes
Plant Derived product

Question 2

Name the alkylating agent subclass

Answer 2

Nitrogen Mustard

Question 3

Name a drug in the N-Mustard family

Answer 3

Cyclophosphamide

Question 4

What is the MOA of cyclophosphamide

Answer 4

Forms a positively charged complex with CA cells DNA causing damage

Question 5

Cyclophosphamide is used to treat

Answer 5

Lymphoma

Question 6

What is the main AE of cyclophosphamide

Answer 6

Myelosuppresion

Question 7

Name the antimetabolite subclass (folate antagonists)

Answer 7

Large folate

*analog of folic acid

Question 8

Name a drug in the Large folate subclass

Answer 8

Methotrexate (MTX)

Question 9

What is the MOA of MTX

Answer 9

Inhibits folic acid by binding to dihydrofolate reductase and thymid synthase

Question 10

What is MTX use to tx

Answer 10

ALL

Question 11

What is the main AE of MTX

Answer 11

Myelosuppression

Question 12

Name the antimetabolite subclass (purine analogues)

Answer 12

Thiolyated purine

Question 13

Name the drug in the thiolyated purine subclass (anti-purine)

Answer 13

thioguanine

Question 14

What is the MOA of thioguanine

Answer 14

Inhibits purine synthesis

Question 15

What is thioguanine use to tx

Answer 15

leukemia

Question 16

What is the main AE associated with thioguanine

Answer 16

Myelosuppression

Question 17

Name the antimetabolite subclass (pyrimidine analogues)

Answer 17

Halogenated pyrimidine

Question 18

Name the halogenated pyrimidine (anti-pyrimidine)

Answer 18

5 Fluorouracil (5-FU)

Question 19

What is the MOA of 5-FU

Answer 19

Inhibits thymid synthetase

Question 20

What is 5-FU used to tx

Answer 20

colon CA

Question 21

What is the main MOA of 5-FU

Answer 21

Myelosuppression

Question 22

How does the anticancer ANTIBIOTICs work

Answer 22

By inhibiting nucleic acid synthesis by directly binding to the nucleic acid template or the polmerizing enzyme

Question 23

Name two drug subclasses used as a antiCA antibiotic

Answer 23

Anthracyclines

Bleomycins

Question 24

Name an anthracycline

Answer 24

Doxorubicin

Question 25

What is the MOA of Doxorubicin

Answer 25

INTERCALATING agent that inserts b/t DNA base pairs in the S-phase of cell division

Question 26

What is Doxorubicin used to tx

Answer 26

Solid tumors

Question 27

What are the main AE associated with Doxorubicin

Answer 27

• • Cardiac toxicity

* Myelosuppression

Question 28

Name a bleomycin

Answer 28

Bleomycin

Question 29

What is the MOA of bleomycin

Answer 29

Cuts DNA strand of CA cells

Question 30

Bleomycin is used to tx

Answer 30

testicular CA

Question 31

What is the main AE associated with bleomycin

Answer 31

Lung toxicity

Question 32

How do Platinum Coordination Complexes work

Answer 32

By forming strong metal complexes with guanine on DNA

*binds N7,06 location

Question 33

Name a Platinum coordination complex

Answer 33

Cisplatin

Question 34

Name two subclasses derived from plant products

Answer 34

Vinca alkaloids

Taxanes

Question 35

Name a Vinca alkaloid

Answer 35

Vincristine

Question 36

What is the MOA of Vincristine

Answer 36

Binds to microtubule tubulin and blocks microtubule formation

Question 37

What is Vincristine used to tx

Answer 37

ALL & Lymphoma

Question 38

What is the main AE for vincristine

Answer 38

NeuroToxicity

Question 39

Name a Taxane

Answer 39

Paclitaxel

Question 40

What is the Paclitaxel MOA

Answer 40

Prevents microtubule disassembly

Question 41

What is paclitaxel used to tx

Answer 41

Ovary and Breast CA

Question 42

What is the main AE of paclitaxel

Answer 42

Myelosuppression