Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Chemotherapy drugs-TRADITIONAL anticancer tx > Flashcards

Chemotherapy drugs-TRADITIONAL anticancer tx Flashcards

1
Q

Name the common traditional anticancer drug class

A 
Alkylating agents
Antimetabolites
Anticancer antibiotics
Platinum Coordination complexes
Plant Derived product
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Name the alkylating agent subclass

A

Nitrogen Mustard

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Name a drug in the N-Mustard family

A

Cyclophosphamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the MOA of cyclophosphamide

A

Forms a positively charged complex with CA cells DNA causing damage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Cyclophosphamide is used to treat

A

Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the main AE of cyclophosphamide

A

Myelosuppresion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Name the antimetabolite subclass (folate antagonists)

A

Large folate

*analog of folic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Name a drug in the Large folate subclass

A

Methotrexate (MTX)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the MOA of MTX

A

Inhibits folic acid by binding to dihydrofolate reductase and thymid synthase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is MTX use to tx

A

ALL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the main AE of MTX

A

Myelosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Name the antimetabolite subclass (purine analogues)

A

Thiolyated purine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Name the drug in the thiolyated purine subclass (anti-purine)

A

thioguanine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the MOA of thioguanine

A

Inhibits purine synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is thioguanine use to tx

A

leukemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the main AE associated with thioguanine

A

Myelosuppression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Name the antimetabolite subclass (pyrimidine analogues)

A

Halogenated pyrimidine

18
Q

Name the halogenated pyrimidine (anti-pyrimidine)

A

5 Fluorouracil (5-FU)

19
Q

What is the MOA of 5-FU

A

Inhibits thymid synthetase

20
Q

What is 5-FU used to tx

A

colon CA

21
Q

What is the main MOA of 5-FU

A

Myelosuppression

22
Q

How does the anticancer ANTIBIOTICs work

A

By inhibiting nucleic acid synthesis by directly binding to the nucleic acid template or the polmerizing enzyme

23
Q

Name two drug subclasses used as a antiCA antibiotic

A

Anthracyclines

Bleomycins

24
Q

Name an anthracycline

A

Doxorubicin

25
Q

What is the MOA of Doxorubicin

A

INTERCALATING agent that inserts b/t DNA base pairs in the S-phase of cell division

26
Q

What is Doxorubicin used to tx

A

Solid tumors

27
Q

What are the main AE associated with Doxorubicin

A
    • Cardiac toxicity

* Myelosuppression

28
Q

Name a bleomycin

A

Bleomycin

29
Q

What is the MOA of bleomycin

A

Cuts DNA strand of CA cells

30
Q

Bleomycin is used to tx

A

testicular CA

31
Q

What is the main AE associated with bleomycin

A

Lung toxicity

32
Q

How do Platinum Coordination Complexes work

A

By forming strong metal complexes with guanine on DNA

*binds N7,06 location

33
Q

Name a Platinum coordination complex

A

Cisplatin

34
Q

Name two subclasses derived from plant products

A

Vinca alkaloids

Taxanes

35
Q

Name a Vinca alkaloid

A

Vincristine

36
Q

What is the MOA of Vincristine

A

Binds to microtubule tubulin and blocks microtubule formation

37
Q

What is Vincristine used to tx

A

ALL & Lymphoma

38
Q

What is the main AE for vincristine

A

NeuroToxicity

39
Q

Name a Taxane

A

Paclitaxel

40
Q

What is the Paclitaxel MOA

A

Prevents microtubule disassembly

41
Q

What is paclitaxel used to tx

A

Ovary and Breast CA

42
Q

What is the main AE of paclitaxel

A

Myelosuppression

Pharmacology (27 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions