miscellaneous antibiotics

Question 1

nitrofurantoin drugs

Answer 1

nitrofurantoin monohydrate/macrocrystals (macrobid) and nitrofurantoin macrocrystals (macrodantin)

Question 2

activity of nitrofurantoin drugs

Answer 2

only e.coli and no pseudomonas(for gram negative) and gram positives-all

Question 3

nitrofurantoin indication

Answer 3

uncomplicated urinary tract infections

Question 4

polymyxin drugs and route

Answer 4

polymixin B (IV) and Colistin (IV, inhaled)

Question 5

polymyxin activity

Answer 5

gram negatives (pseudo, acinetobacter, some enterobactericiae) and no gram positive or anaerobes

Question 6

polymixin indications

Answer 6

MDR pseudomonas and acinetobacter infections when no other alternatives are available(no empiric use) and restricted to ID consults

Question 7

would you choose polymixin B or colistin?

Answer 7

polymixin B because easier dosing, no renal adjustment(can’t be used for UTI though), and less nephrotoxicity

Question 8

fidaxomicin

Answer 8

PO, one of the first lines for C. diff colitis, not systemically absorbed

Question 9

fosfomycin

Answer 9

for uncomplicated UTIs only and broad-spectrum activity