midterm 1 doses

Question 1

penicillin VK

Answer 1

250-500 gm PO QID

Question 2

zosyn

Answer 2

3.375-4.5 mg IV qh6

Question 3

amoxicillin

Answer 3

250-500 mg PO q8h

Question 4

amoxicillin/clavulanic acid

Answer 4

875 mg po BID

Question 5

cefazolin

Answer 5

1-2 gm IV q8h

Question 6

cephalexin

Answer 6

250-500 mg PO q6h

Question 7

ceftriaxone (non CNS infection)

Answer 7

1-2 gm IV q24h

Question 8

ceftriaxone (CNS infection)

Answer 8

2 g IV q12h

Question 9

cefdinir

Answer 9

300 mg PO BID

Question 10

cefepime

Answer 10

1-2 gm IV q8-12 hr

Question 11

ertapenem

Answer 11

1 gm IV q24h

Question 12

azithromycin (respiratory tract infection)

Answer 12

500 mg PO/IV on day 1, 250 mg PO/IV on days 2-5

Question 13

azithromycin with gonococcal/non-gonococcal STD

Answer 13

1 g PO once

Question 14

ciprofloxacin PO

Answer 14

250-750 mg PO BID

Question 15

ciprofloxacin IV

Answer 15

400 mg IV q8-12h

Question 16

levofloxacin

Answer 16

250-750 mg IV/PO qday

Question 17

bactrim strengths

Answer 17

DS is 400 mg SMX/80mg TMP and SS is 800 mg SMX/160 mg TMP

Question 18

bactrim dosing for UTI

Answer 18

1 DS PO BID

Question 19

clindamycin

Answer 19

300-450 mg PO q6-8 hr

Question 20

metronidazole

Answer 20

500 mg IV/PO q8-12h

Question 21

linezolid

Answer 21

600 mg PO q12h

Question 22

what weight do you use for aminoglycosides

Answer 22

actual if ABW<IBW, IBW if ABW>IBW, adjBW if obese

Question 23

initial aminoglycoside once daily dosing

Answer 23

7 mg/kg (round to nearest 10?)

Question 24

aminoglycoside initial dose interval based on CrCl

Answer 24

at least 60 (q24h), 40-59 (q36h), 20-39 (q48h), less than 20 (monitor and administer next dose when <1 mcg/ml)

Question 25

how to use the hartford nomogram for amikacin

Answer 25

measure the concentration, then divide by 2 and use the graph to adjust interval

Question 26

multiple-daily dosing for aminoglycoside

Answer 26

CrCl above 50, 1.7-2 mg/kg q8h

Question 27

synergistic aminoglycoside dosing

Answer 27

assume normal renal function, 1mg/kg IV q8h

Question 28

initial vancomycin dosing

Answer 28

15-20 mg/kg IV q 8-12h and round to nearest 250mg

Question 29

weight to use for vancomycin

Answer 29

non-obese is ABW, obese is adjBW

Question 30

macrobid

Answer 30

100 mg po BID

Question 31

macrodantin

Answer 31

100 mg po BID

Question 32

fluconazole normal and susceptible dose-dependent Candida

Answer 32

100-400 mg IV/PO qday; candida= 12 mg/kg or 800 mg/day

Question 33

drugs and dosing for bacterial meningitis caused by L. monocytogenes

Answer 33

ampicillin 2g IV q4h+gentamicin 1.5 mg/kg IV q8h OR PCN G 4 MU IV q4h + gentamicin 1.5 mg/kg IV q8hr

Question 34

drugs and dosing for bacterial meningitis caused by S. pneumoniae

Answer 34

ampicillin 2g IV q4hr OR PCN G 4 MU IV q4h OR ceftriaxone 2g IV q12h

Question 35

drugs and dosing for bacterial meningitis caused by N. meningitidis

Answer 35

ampicillin 2 IV q4h OR PCN G 4 MU IV q4h OR ceftriaxone 2g IV q12h

Question 36

dexamethasone

Answer 36

used if bacterial meningitis is suspected and continue if pneumococcal disease is confirmed: 0.15 mg/kg IV q6h for 4 days (use in empiric therapy)

Question 37

acyclovir (bacterial meningitis)

Answer 37

use empirically for if meningitis is suspected because it could be from HSV : 10mg/kg IV q8h with IBW

Question 38

acyclovir (viral encephalitis)

Answer 38

caused by HSV start with 10mg/kg IV q8h for 14-21 days with IBW

Question 39

ampicillin

Answer 39

1-2 grams IV q4-6 h