cephalosporins V2

Question 1

1st gen ceph

Answer 1

(cefazolin and cephalexin) and activity against MSSA and strep so it can be used for MSSA or streptococci infections

Question 2

2nd gen true ceph

Answer 2

are cefuroxime
- this have activity against MSSA and strep and increased gram negative activity like H flu and morexella. this is mainly to treat upper respiratory tract infections (CA)

Question 3

2nd gen cephamycins

Answer 3

cefotetan and cefoxitin
- improved activity against gram negative and anaerobes, but less gram positive activity and used as prophylaxis for intra-abdominal infections

Question 4

3rd gen ceph

Answer 4

(ceftriaxone and cefdinir) better gram negative and can treat gram positives of streptococci and common respiratory/enteric gram negative pathogens
- no enterococci, pseudomonas, and MSSA varies
- used for CA and HA infections liked CNS, PNA, UTIs, SSTI

Question 5

4th gen ceph

Answer 5

(cefepime) this can treat gram negatives including pseudomonas and enterobactericiae
gram positives including MSSA and strep and AmpC producing strains
used for HA infections like PNA, UTI, wound infections

Question 6

anti-MRSA cephalosporin

Answer 6

ceftaroline- good against gram positive (MRSA and MSSA not so much enterococci) and enteric/resp gram negative but not including pseudomonas

Question 7

other cephalosporins

Answer 7

ceftazidime/avibactam can treat carbapanemase producing strains and ceftolozane/tazobactam can treat MDR pseudomonas(but not carbapanemase producing strains)

Question 8

cefiderocol

Answer 8

active against MDR gram negative bacteria including carbapenemase producing strains