Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PHRM 865 > Miscellaneous Agents > Flashcards

Miscellaneous Agents Flashcards

1
Q

tetracycline drugs

A

tetracycline
minocycline
doxycycline

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

tetracycline analog drugs

A

tigecycline
eravacycline
omadacyclin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

mechanism of action tetracycline and analogs

A

bind reversibly to 30S ribosome to inhibit protein synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

tetracycline and analogs static or cidal, time or conc dep

A

static
time dependent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

TMP-SMX MOA

A

sequential inhibition of microbial folic acid synthesis pathway by inhibiting bacterial dihydropepteroate synthetase and dihydrofolate reductase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

sulfamethoxazole MOA

A

inhibits dihydropteroate synthetase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

trimethorpim MOA

A

inhibits activity of bacterial dihydrofolate reductase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

polymixin B and Colistin MOA

A

binds phospholipids in cell membrane causing displacement of Ca and Mg, which leads to changes in cell wall permeability and leakage of cellular contents

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

TMZ-SMX cidal or static, conc or time

A

bactericidal
time dependent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

polymixin B and colistin citdal or static, conc or time

A

bactericidal
concentration dependent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

clindamycin MOA

A

inhibits protein synthesis by binding to 50S ribosomal subunit reversibly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

clindamycin static or cidal time or conc

A

bacteriostatic
time dependent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

metronidazole MOA

A

inhibits DNA synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

metronidazole cidal or static, conc or time dep

A

bactericidal
concentration dependent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

resistance mechanism tetracyclines

A

tetracycline specific efflux pumps
ribosomal protection proteins
enzymatic inactivation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

resistance mechanism tetracycline analogs

A

multi drug efflux pumps

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

resistance mechanism TMX-SMP

A

mutation in dihydrofolate reductase or dihydropteroate synthase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

polymixins resistance mechanism

A

alteration in outer cell membrane
(dec in Ca or Mg content, dec lipopolysacchardie content, dec outer membrane proteins)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

clindamycin resistance mechanism

A

alteration in ribosomal binding site
NOT efflux pumps

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

metronidazole resistance mechanism

A

altered growth requirements, reduced transcription of ferredoxin gene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

tetracyclines spectrum of activity

A

gram positive
gram negative
anaerobes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

tetracycline analogs spectrum of activity

A

gram positive
gram negative
anaerobes

23
Q

TMP-SMX spectrum of activity

A

gram positive
gram negative

24
Q

polymyxins spectrum of activity

A

gram negative only

25
Q

clindamycin spectrum of activity

A

gram positive
anaerobes

26
Q

metronidazole spectrum of activity

A

only anaerobes

27
Q

tetracyclines target organisms

A

MSSA
MRSA
legionella

28
Q

tetracycline analogs target organisms

A

MSSA
MRSA
BDA

29
Q

TMP-SMX target organisms

30
Q

polymyxins target organisms

A

pseudomonas

31
Q

clindamycin target organisms

A

MSSA
MRSA
BDA
ADA

32
Q

metronidazole target organisms

A

c. diff
BDA

33
Q

tetracyclines - CSF penetration?

A

minimal CSF penetration

34
Q

TMP-SMX - CSF penetration?

A

yes with inflamed meninges

35
Q

polymyxins - CSF penetration?

36
Q

clindamycin - CSF penetration?

37
Q

metronidazole CSF penetration?

38
Q

which miscellaneous need renal dose adjust?

A

tetracycline
SMP-TMZ CrCl<30
colistin CrCl <80

39
Q

adverse effects of tetracyclines and tigecycline

A

N/V
photosensitivity

40
Q

adverse effects of TMP-SMX

A

GI
Leukopenia, thrombocytopenia
hypersensitivity
crystalluria
hyperkalemia
renal insufficiency

41
Q

adverse effects of polymyxins

A

nephrotoxicity
neurotoxicity (dizzy,weak)

42
Q

advers effects of clindamycin

A

c. diff colitis
hepatotoxicit

43
Q

metronidazole adverse effects

A

metallic taste
stomatitis
peripheral neuropathy
seizures
CNS disorders

44
Q

which miscellaneous agents interact with chelating agents

A

oral tetracyclines
omadacycline
(ZICAM, bismuth salicylate, dairy)

45
Q

misc agents interacting with warfarin

A

TMP-SMX
metronidazole

46
Q

which misc interacts with alcochol

A

metronidazole

47
Q

can you use tetracyclines in pregnancy

48
Q

can you use TMP-SMX in pregnancy

49
Q

can you use clindamycin in pregnancy

50
Q

can you use polymyxins in pregnancy

51
Q

can you use metronidazole in pregnancy

52
Q

which misc drugs can we not use in children

A

tetracyclines and analogs, teeth discolor and decreased bone growth

53
Q

CMS which dosing weight

54
Q

polymyxin which dosing weight

PHRM 865 (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions