Cushman random Flashcards
when do we use vanc
c. diff unresponsive to metronidazole
MRSA
side effects of vanc
nephrotox
ototox
red man syndrome
which lipoglycopeptides have long halftime
dalbavancin and oritavancin
what is synercid bacteriostatic against
enterococcus faecium
what is synercid bacteriocidal against
MR staph and MS staph
quinupristin resistance mechanism
adenine methylation in 23S RNA hinders quinupristin from binding
what is virginiamycin
looks like synercid and is in livestock so there is resistance from this
synercid drug interactions
cyp 3a4
linezolid used for what
multi drug resistant gram +
linezolid resistance
G to U substituion reduces affinity for linezolid binding to 23S RNA
linezolid side effects
GI, N/V , diarrhea
thrush
tongue discolor
myelosuppression
thrombocytopenia
neuropathy
linezolid drug interactions
monoamine oxidase inhibitor
tyramine containing foods (cheddar, red wine,camembert, stiliton)
aminoglycoside toxicity
ototoxicity - irreversible
nephrotoxicity - reversible
aminoglycoside effect on respiratory
respiratory paralysis - reversed by calcium gluconate, neostigmine
can aminoglycosides and penicillins be given together
yes but in seperate arms
neomycin indication
traveler diarrhea
paromomycin indication
travelers diarrhea
dwarf tapeworm
beef tapeworm
macrolide degradation
lactone ester hydrolysis
adenine added to 23S RNA to prevent binding of macrolides to 50S unit
adenine to guanine mutation
macrolide drug interactions
clarithromycin and erythromycin inhibit CYP3A4
macrolides side effects
GI
skin reactions
jaundice
pyloric stenosis
what drug given with leucovorin for AIDs pts
clindamycin
big side effect of clindamycin
diarrhea and mega colon
how does
