Miscellaneous

Question 1

Steroids - adverse effects

Answer 1

Heart attack
Stroke
Hepatic toxicity
Renal failure
Serious psychiatric problems 
Reduction of testes and sperm production.
Hirsutism
Increased aggression.

Question 2

Inhalants - adverse effects

Answer 2

Cardiac arrest.

Toxicity in brain, heart, kidney, liver.

Question 3

Haloperidol should not be used in which overdose? And why?

Answer 3

Cocaine. Lowers seizure threshold.

Question 4

Drugs used to treat withdrawal

Answer 4

Naloxone - opioid withdrawal.
Flumazenil - benzodiazepine withdrawal.
Lorazepam - control agitation.
Haloperidol - control psychosis.
Lorazepam/chlordiazepoxide - alcohol withdrawal.
Methadone - opioid withdrawal.
Clonidine - alcohol, opioid, nicotine withdrawal.

Question 5

Treatment of dependence

Answer 5

Disulfiram and acamprosate calcium
- alcohol dependence.
Methadone, LAAM, buprenorphine - opioid dependence.
Naltrexone - alcohol and opioid dependence.
Nicotine patches ect, varenicline, bupropion - smoking cessation.

Question 6

Disulfiram - MOA

Answer 6

Inhibits acetaldehyde dehydrogenase. When alcohol is ingested - nausea, profuse vomiting, sweating, flushing, palpitations, dyspnea.

Question 7

Drugs causing disulfiram-like reactions with alcohol

Answer 7

Metronidazole, some third generation cephalosporins

Question 8

Naltrexone - MOA

Answer 8

Directly block opioid receptors.