Cannabis and its derivatives

Question 1

Cannabis - MOA

Answer 1

Binds to cannabinoid receptors in neurons, inhibition of adenylyl cyclase and inhibition of cAMP production.
Effects on ACh, DOP and SER.

Question 2

Endogenous ligand for cannabinoid receptors

Answer 2

Anandamide

Question 3

TCH can be detected in…

Answer 3

Fats

Question 4

Signs of marijuana intoxication

Answer 4

Loquacity, rapid speech.
Euphoria, hallucinations (high doses), jocularity, sensory intensification.
Hypertension, tachycardia.
Conjunctivitis, dry mouth, increased appetite, tightness in chest.

Question 5

Treatment of marijuana intoxification

Answer 5

Lorazepam for agitation.

Give reassurance and support vital functions.

Question 6

Marijuana - signs of withdrawal

Answer 6

Irritability, mild agitation, sleep disturbances.

Nausea, stomach cramps.

Question 7

Phases of marijuana intoxication

Answer 7

Stimulant phase: Euphoria, altered sense of time, increased visual acuity, difficulty in concentrating, impaired short-term memory.
Depressive phase: drowsiness, lethargy, increased appetite.

Question 8

Marijuana - adverse effects

Answer 8

Decreased testosterone level.
Low birth weight.
Fetal malformations.
Decreased ovulation.
Reduced aggressiveness.
Schizophrenia (adolescents) - controversial. 
Tachycardia

Question 9

Cannabis - clinical use

Answer 9

Asthma, glaucoma, nausea, vomiting.

Question 10

Peripheral effects of cannabis

Answer 10

Bronchodilation.
Decreased intraocular pressure.
Inhibition of nausea.

Question 11

Synthetic cannabis derivatives and their indications

Answer 11

Dronabinol and nabilone - nausea from chemotherapy, stimulation of appetite in AIDS.